Enhancement of solution NMR and MRI with laser-polarized xenon

G. Navon; Y. Q. Song; T. Rõõm; S. Appelt; R. E. Taylor; A. Pines

doi:10.1126/science.271.5257.1848

Enhancement of solution NMR and MRI with laser-polarized xenon

G. Navon, Y. Q. Song, T. Rõõm, S. Appelt, R. E. Taylor, A. Pines^*

^*Corresponding author for this work

School of Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

Optical pumping with laser light can be used to polarize the nuclear spins of gaseous xenon-129. When hyperpolarized xenon-129 is dissolved in liquids, a time-dependent departure of the proton spin polarization from its thermal equilibrium is observed. The variation of the magnetization is an unexpected manifestation of the nuclear Overhauser effect, a consequence of cross-relaxation between the spins of solution protons and dissolved xenon-129. Time-resolved magnetic resonance images of both nuclei in solution show that the proton magnetization is selectively perturbed in regions containing spin-polarized xenon-129. This effect could find use in nuclear magnetic resonance spectroscopy of surfaces and proteins and in magnetic resonance imaging.

Original language	English
Pages (from-to)	1848-1851
Number of pages	4
Journal	Science
Volume	271
Issue number	5257
DOIs	https://doi.org/10.1126/science.271.5257.1848
State	Published - 29 Mar 1996

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AU - Song, Y. Q.

AU - Rõõm, T.

AU - Appelt, S.

AU - Taylor, R. E.

AU - Pines, A.

PY - 1996/3/29

Y1 - 1996/3/29

N2 - Optical pumping with laser light can be used to polarize the nuclear spins of gaseous xenon-129. When hyperpolarized xenon-129 is dissolved in liquids, a time-dependent departure of the proton spin polarization from its thermal equilibrium is observed. The variation of the magnetization is an unexpected manifestation of the nuclear Overhauser effect, a consequence of cross-relaxation between the spins of solution protons and dissolved xenon-129. Time-resolved magnetic resonance images of both nuclei in solution show that the proton magnetization is selectively perturbed in regions containing spin-polarized xenon-129. This effect could find use in nuclear magnetic resonance spectroscopy of surfaces and proteins and in magnetic resonance imaging.

AB - Optical pumping with laser light can be used to polarize the nuclear spins of gaseous xenon-129. When hyperpolarized xenon-129 is dissolved in liquids, a time-dependent departure of the proton spin polarization from its thermal equilibrium is observed. The variation of the magnetization is an unexpected manifestation of the nuclear Overhauser effect, a consequence of cross-relaxation between the spins of solution protons and dissolved xenon-129. Time-resolved magnetic resonance images of both nuclei in solution show that the proton magnetization is selectively perturbed in regions containing spin-polarized xenon-129. This effect could find use in nuclear magnetic resonance spectroscopy of surfaces and proteins and in magnetic resonance imaging.

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Enhancement of solution NMR and MRI with laser-polarized xenon

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