Enhancement of macrophage stimulation by lipoteichoic acid and the costimulant hemoglobin is dependent on toll-like receptors 2 and 4

Kathleen H. Cox, Itzhak Ofek, David L. Hasty

Research output: Contribution to journalArticlepeer-review

Abstract

Macrophage stimulation by lipoteichoic acid (LTA) and hemoglobin (Hb) requires Toll-like receptors 2 and 4 (TLR2 and -4). There are two distinct temporal phases off interleukin-6 (IL-6) production. The first results in a slight enhancement of IL-6 secretion in response to LTA pies Hb compared to that with LTA alone and is TLR4 independent. The second requires TLR4 and accounts for most of the additional stimulation seen with LTA plus Hb.

Original languageEnglish
Pages (from-to)2638-2641
Number of pages4
JournalInfection and Immunity
Volume75
Issue number5
DOIs
StatePublished - May 2007

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