Enhancement of macrophage stimulation by lipoteichoic acid and the costimulant hemoglobin is dependent on toll-like receptors 2 and 4

Kathleen H. Cox; Itzhak Ofek; David L. Hasty

doi:10.1128/IAI.01320-06

Enhancement of macrophage stimulation by lipoteichoic acid and the costimulant hemoglobin is dependent on toll-like receptors 2 and 4

Kathleen H. Cox, Itzhak Ofek, David L. Hasty^*

^*Corresponding author for this work

Clinical Microbiology and Immunology

Research output: Contribution to journal › Article › peer-review

Abstract

Macrophage stimulation by lipoteichoic acid (LTA) and hemoglobin (Hb) requires Toll-like receptors 2 and 4 (TLR2 and -4). There are two distinct temporal phases off interleukin-6 (IL-6) production. The first results in a slight enhancement of IL-6 secretion in response to LTA pies Hb compared to that with LTA alone and is TLR4 independent. The second requires TLR4 and accounts for most of the additional stimulation seen with LTA plus Hb.

Original language	English
Pages (from-to)	2638-2641
Number of pages	4
Journal	Infection and Immunity
Volume	75
Issue number	5
DOIs	https://doi.org/10.1128/IAI.01320-06
State	Published - May 2007

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abstract = "Macrophage stimulation by lipoteichoic acid (LTA) and hemoglobin (Hb) requires Toll-like receptors 2 and 4 (TLR2 and -4). There are two distinct temporal phases off interleukin-6 (IL-6) production. The first results in a slight enhancement of IL-6 secretion in response to LTA pies Hb compared to that with LTA alone and is TLR4 independent. The second requires TLR4 and accounts for most of the additional stimulation seen with LTA plus Hb.",

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AU - Hasty, David L.

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N2 - Macrophage stimulation by lipoteichoic acid (LTA) and hemoglobin (Hb) requires Toll-like receptors 2 and 4 (TLR2 and -4). There are two distinct temporal phases off interleukin-6 (IL-6) production. The first results in a slight enhancement of IL-6 secretion in response to LTA pies Hb compared to that with LTA alone and is TLR4 independent. The second requires TLR4 and accounts for most of the additional stimulation seen with LTA plus Hb.

AB - Macrophage stimulation by lipoteichoic acid (LTA) and hemoglobin (Hb) requires Toll-like receptors 2 and 4 (TLR2 and -4). There are two distinct temporal phases off interleukin-6 (IL-6) production. The first results in a slight enhancement of IL-6 secretion in response to LTA pies Hb compared to that with LTA alone and is TLR4 independent. The second requires TLR4 and accounts for most of the additional stimulation seen with LTA plus Hb.

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JO - Infection and Immunity

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SN - 0019-9567

IS - 5

ER -

Enhancement of macrophage stimulation by lipoteichoic acid and the costimulant hemoglobin is dependent on toll-like receptors 2 and 4

Abstract

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