Abstract
Macrophage stimulation by lipoteichoic acid (LTA) and hemoglobin (Hb) requires Toll-like receptors 2 and 4 (TLR2 and -4). There are two distinct temporal phases off interleukin-6 (IL-6) production. The first results in a slight enhancement of IL-6 secretion in response to LTA pies Hb compared to that with LTA alone and is TLR4 independent. The second requires TLR4 and accounts for most of the additional stimulation seen with LTA plus Hb.
Original language | English |
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Pages (from-to) | 2638-2641 |
Number of pages | 4 |
Journal | Infection and Immunity |
Volume | 75 |
Issue number | 5 |
DOIs | |
State | Published - May 2007 |