TY - JOUR
T1 - Enhancement of lymphocyte and macrophage function in vitro by lithium chloride
AU - Shenkman, Louis
AU - Borkowsky, William
AU - Holzman, Robert S.
AU - Shopsin, Baron
N1 - Funding Information:
i Supported in part by USPHS grant Nos. AL-00005-17. CA - 16247-03, and MH-07436. 2 Louis Shenkman is an Irma T. Hirsch1 Career Scientist.
PY - 1978/6
Y1 - 1978/6
N2 - Lithium chloride, an inhibitor of adenylate cyclase, augmented several in vitro immune reactions. Lithium increased rosette formation and thymidine incorporation by lymphocytes and phagocytosis by macrophages. Prostaglandin E1 (10-4 M), an adenylate cyclase stimulator, inhibited lymphocyte response to phytohemagglutinin. Lithium reversed this effect, suggesting that its actions on lymphocytes may be mediated, at least in part, by inhibiting adenylate cyclase.
AB - Lithium chloride, an inhibitor of adenylate cyclase, augmented several in vitro immune reactions. Lithium increased rosette formation and thymidine incorporation by lymphocytes and phagocytosis by macrophages. Prostaglandin E1 (10-4 M), an adenylate cyclase stimulator, inhibited lymphocyte response to phytohemagglutinin. Lithium reversed this effect, suggesting that its actions on lymphocytes may be mediated, at least in part, by inhibiting adenylate cyclase.
UR - http://www.scopus.com/inward/record.url?scp=0018142568&partnerID=8YFLogxK
U2 - 10.1016/0090-1229(78)90026-0
DO - 10.1016/0090-1229(78)90026-0
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AN - SCOPUS:0018142568
SN - 0090-1229
VL - 10
SP - 187
EP - 192
JO - Clinical Immunology and Immunopathology
JF - Clinical Immunology and Immunopathology
IS - 2
ER -