Following preliminary results in animal studies demonstrating that thyroxine (T 4) injected directly into the fetus or the amniotic sac is capable of enhancing fetal lung maturity, a trial of thyroxine treatment in man was carried out. Two hundred micrograms of T 4 were injected intra-amniotically in eight women with high-risk pregnancies in which premature delivery was inevitable or indicated. Fetal lung maturity was evaluated by a recently developed, accurate, and rapid method using the microviscosity value ε (this being the linear expression of the polarization value P) of the lipid assembly of the amniotic fluid as a parameter of the surfactant content. ε Values, which were very high before T 4 injection, dropped steeply to below the value of 4.344, indicating fetal lung maturity. Eight newborn infants delivered, five by caesarean section, soon after the T 4 injection did not develop respiratory distress syndrome, although they were born prematurely. Intra-amniotic injection of T 4 appears to be of therapeutic value in enhancing fetal lung maturity.
|Number of pages||5|
|Journal||American Journal of Obstetrics and Gynecology|
|State||Published - 1978|