Enhancement of anti-Shigella lipopolysaccharide (LPS) response by addition of the cholera toxin B subunit to oral and intranasal proteosome-Shigella flexneri 2a LPS vaccines

N. Orr*, R. Arnon, G. Rubin, D. Cohen, H. Bercovier, G. H. Lowell

*Corresponding author for this work

Research output: Contribution to journalComment/debate

Abstract

Addition of the cholera toxin B subunit to oral and intranasal proteosome- Shigella flexneri 2a lipopolysaccharide vaccines improved their immunogenicities. Enhancement of anti-O-Shigella immunoglobulin A levels was most evident in lung lavages following oral immunization and in lung and intestinal fluids when suboptimal doses were used with either immunization route.

Original languageEnglish
Pages (from-to)5198-5200
Number of pages3
JournalInfection and Immunity
Volume62
Issue number11
StatePublished - 1994
Externally publishedYes

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