Enhanced thromboxane synthesis with extradural anaesthesia

A. Khazam*, J. M. Klausner, S. Lelcuk

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Reperfusion of limb following tourniquet ischaemia increases plasma concentration of thromboxane (TxB2). The study examined TxB2 production during the ischaemia and reperfusion of femoral-popliteal bypass surgery and the effect of anaesthetic technique. Patients (n = 19) were randomly allocated to receive either general (GA) or extradural (EA)anaesthesia. TxB2 concentrations were similar both before and after anaesthesia in the two groups. Clamping the femoral artery in patients given GA resulted in a small but insignificant increase in TxB2 concentration. However, in the EA group clamping resulted in a 10-fold increase in TxB2 concentration (P < 0.05). To demonstrate that anaesthesia itself was not the stimulus to TxB2 synthesis, patients undergoing inguinal herniorrhaphy (n = 13) received either GA or EA. There were no subsequent changes in TxB2 concentration in each group. The results indicate that EA but not GA maintains collateral flow during femoral arterial clamping and provides the oxygen needed for generati9n of TxB2 during ischaemia

Original languageEnglish
Pages (from-to)238-239
Number of pages2
JournalBritish Journal of Anaesthesia
Issue number2
StatePublished - Feb 1990
Externally publishedYes


  • Anaestjetic technique: extradural


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