Enhanced Nanoassembly-Incorporated Antibacterial Composite Materials

Lee Schnaider, Moumita Ghosh, Darya Bychenko, Irena Grigoriants, Sarah Ya'Ari, Tamar Shalev Antsel, Shlomo Matalon, Rachel Sarig, Tamar Brosh, Raphael Pilo, Ehud Gazit, Lihi Adler-Abramovich*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

The rapid advancement of peptide- and amino-acid-based nanotechnology offers new approaches for the development of biomedical materials. The utilization of fluorenylmethyloxycarbonyl (Fmoc)-decorated self-assembling building blocks for antibacterial and anti-inflammatory purposes represents promising advancements in this field. Here, we present the antibacterial capabilities of the nanoassemblies formed by Fmoc-pentafluoro-l-phenylalanine-OH, their substantial effect on bacterial morphology, as well as new methods developed for the functional incorporation of these nanoassemblies within resin-based composites. These amalgamated materials inhibit and hinder bacterial growth and viability and are not cytotoxic toward mammalian cell lines. Importantly, due to the low dosage required to confer antibacterial activity, the integration of the nanoassemblies does not affect their mechanical and optical properties. This approach expands on the growing number of accounts on the intrinsic antibacterial capabilities of self-assembling building blocks and serves as a basis for further design and development of enhanced composite materials for biomedical applications.

Original languageEnglish
JournalACS Applied Materials and Interfaces
DOIs
StatePublished - 1 Jan 2019

Keywords

  • antibacterial materials
  • biomaterials
  • nanostructures
  • resin composite restoratives
  • self-assembly

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