Enhanced electroretinogram in cats induced by exposure to mercury acetate

S. Gitter; A. Pardo; N. Kariv; U. Yinon

doi:10.1016/0300-483X(88)90081-9

Enhanced electroretinogram in cats induced by exposure to mercury acetate

S. Gitter^*, A. Pardo, N. Kariv, U. Yinon

^*Corresponding author for this work

Eye Institute (Goldschleger)

Sheba Medical Center at Tel Hashomer

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

The present study was undertaken in order to verify whether, and how, retinal functions are affected by subacute poisoning with organic mercury. Mercury acetate in various concentrations (0.025-0.25 mg/kg per day) was injected subcutaneously every second day to adult cats (N = 20) throughout a 2.5-4.0-week period. The electroretinogram (ERG) was recorded and the Hg²⁺ concentrations in the blood were determined. In nearly 90% of the intoxicated cats an enhanced electroretinogram (scotopic b-wave amplitude) was found as compared to its level in the normal control cats (N = 10). The latency of the ERG was found to be appropriately shorter, up to a maximal difference of nearly 20% in comparison to the controls. Hg²⁺ was present in the blood of the exposed cats during a 2.5-month period following the exposure. It is concluded that exposure to mercury acetate induces a permanent increase in the excitability level of the cat's retina.

Original language	English
Pages (from-to)	67-76
Number of pages	10
Journal	Toxicology
Volume	51
Issue number	1
DOIs	https://doi.org/10.1016/0300-483X(88)90081-9
State	Published - Sep 1988

Funding

Funders	Funder number
Committee for the Prevention and Research in Work, Ministry for Welfare and Work, Government of Israel
Tel Aviv University

Keywords

Cats
Electroretinography
Mercury acetate
Subacute poisoning
Toxicological monitoring

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/0300-483X(88)90081-9

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title = "Enhanced electroretinogram in cats induced by exposure to mercury acetate",

abstract = "The present study was undertaken in order to verify whether, and how, retinal functions are affected by subacute poisoning with organic mercury. Mercury acetate in various concentrations (0.025-0.25 mg/kg per day) was injected subcutaneously every second day to adult cats (N = 20) throughout a 2.5-4.0-week period. The electroretinogram (ERG) was recorded and the Hg2+ concentrations in the blood were determined. In nearly 90% of the intoxicated cats an enhanced electroretinogram (scotopic b-wave amplitude) was found as compared to its level in the normal control cats (N = 10). The latency of the ERG was found to be appropriately shorter, up to a maximal difference of nearly 20% in comparison to the controls. Hg2+ was present in the blood of the exposed cats during a 2.5-month period following the exposure. It is concluded that exposure to mercury acetate induces a permanent increase in the excitability level of the cat's retina.",

keywords = "Cats, Electroretinography, Mercury acetate, Subacute poisoning, Toxicological monitoring",

author = "S. Gitter and A. Pardo and N. Kariv and U. Yinon",

note = "Funding Information: Zimmerman from the Physiological Laboratory is acknowledged for the maintenance of the electronic equipment. Many thanks to Mrs. I. Yosef from the Glasberg Tower for Medical Research for her endless patience in treating our cats, and to Dr. A. Ben-David and Mr. R. Pridor from the Institute of Occupational Health for their useful assistance during the various stages of the research. The research was supported by a grant from the Committee for the Prevention and Research in Work, Ministry for Welfare and Work, Government of Israel and by the Andy Lebach Chair for Clinical Pharmacology and Toxicology, Sackler Faculty of Medicine, Tel Aviv University.",

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T1 - Enhanced electroretinogram in cats induced by exposure to mercury acetate

AU - Gitter, S.

AU - Pardo, A.

AU - Kariv, N.

AU - Yinon, U.

N1 - Funding Information: Zimmerman from the Physiological Laboratory is acknowledged for the maintenance of the electronic equipment. Many thanks to Mrs. I. Yosef from the Glasberg Tower for Medical Research for her endless patience in treating our cats, and to Dr. A. Ben-David and Mr. R. Pridor from the Institute of Occupational Health for their useful assistance during the various stages of the research. The research was supported by a grant from the Committee for the Prevention and Research in Work, Ministry for Welfare and Work, Government of Israel and by the Andy Lebach Chair for Clinical Pharmacology and Toxicology, Sackler Faculty of Medicine, Tel Aviv University.

PY - 1988/9

Y1 - 1988/9

N2 - The present study was undertaken in order to verify whether, and how, retinal functions are affected by subacute poisoning with organic mercury. Mercury acetate in various concentrations (0.025-0.25 mg/kg per day) was injected subcutaneously every second day to adult cats (N = 20) throughout a 2.5-4.0-week period. The electroretinogram (ERG) was recorded and the Hg2+ concentrations in the blood were determined. In nearly 90% of the intoxicated cats an enhanced electroretinogram (scotopic b-wave amplitude) was found as compared to its level in the normal control cats (N = 10). The latency of the ERG was found to be appropriately shorter, up to a maximal difference of nearly 20% in comparison to the controls. Hg2+ was present in the blood of the exposed cats during a 2.5-month period following the exposure. It is concluded that exposure to mercury acetate induces a permanent increase in the excitability level of the cat's retina.

AB - The present study was undertaken in order to verify whether, and how, retinal functions are affected by subacute poisoning with organic mercury. Mercury acetate in various concentrations (0.025-0.25 mg/kg per day) was injected subcutaneously every second day to adult cats (N = 20) throughout a 2.5-4.0-week period. The electroretinogram (ERG) was recorded and the Hg2+ concentrations in the blood were determined. In nearly 90% of the intoxicated cats an enhanced electroretinogram (scotopic b-wave amplitude) was found as compared to its level in the normal control cats (N = 10). The latency of the ERG was found to be appropriately shorter, up to a maximal difference of nearly 20% in comparison to the controls. Hg2+ was present in the blood of the exposed cats during a 2.5-month period following the exposure. It is concluded that exposure to mercury acetate induces a permanent increase in the excitability level of the cat's retina.

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KW - Electroretinography

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KW - Subacute poisoning

KW - Toxicological monitoring

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Enhanced electroretinogram in cats induced by exposure to mercury acetate

Abstract

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Keywords

UN SDGs

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