Enemy of the (immunosuppressed) state: An update on the pathogenesis of Aspergillus fumigatus infection

Ronen Ben-Ami, Russell E. Lewis, Dimitrios P. Kontoyiannis

Research output: Contribution to journalReview articlepeer-review

Abstract

Aspergillus fumigatus is an opportunistic filamentous fungus that is currently the most frequent cause of invasive fungal disease in immunosuppressed individuals. Recent advances in our understanding of the pathogenesis of invasive aspergillosis have highlighted the multifactorial nature of A. fumigatus virulence and the complex interplay between host and microbial factors. In this review, we outline current concepts of immune recognition and evasion, angioinvasion and angiogenesis, secondary metabolism and the fungal stress response, and their respective roles in this often lethal infection.

Original languageEnglish
Pages (from-to)406-417
Number of pages12
JournalBritish Journal of Haematology
Volume150
Issue number4
DOIs
StatePublished - Aug 2010
Externally publishedYes

Keywords

  • Aspergillus fumigatus
  • immunosuppressed state
  • pathogenesis

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