TY - JOUR
T1 - Endothelin/sarafotoxin receptor induced phosphoinositide turnover
T2 - Effects of pertussis and cholera toxins and of phorbol ester
AU - Galron, Ronit
AU - Bdolah, Avner
AU - Kloog, Yoel
AU - Sokolovsky, Mordechai
PY - 1990/9/28
Y1 - 1990/9/28
N2 - The induction of phosphoinositide hydrolysis (PI) by endothelin/sarafotoxin (ET/SRTX) receptors in rat heart myocytes was investigated by the use of bacterial toxins as well as a phorbol ester. Both pertussis- and choleratoxin enhanced the stimulation of PI hydrolysis. Phorbol ester treatment of the myocytes for short periods distinguished between two types of PI-hydrolysis, the one induced by endothelins and the other by sarafotoxins. The possible mediation of G-protein (s) in the induction by ET/SRTX receptors of PI-hydrolysis is discussed.
AB - The induction of phosphoinositide hydrolysis (PI) by endothelin/sarafotoxin (ET/SRTX) receptors in rat heart myocytes was investigated by the use of bacterial toxins as well as a phorbol ester. Both pertussis- and choleratoxin enhanced the stimulation of PI hydrolysis. Phorbol ester treatment of the myocytes for short periods distinguished between two types of PI-hydrolysis, the one induced by endothelins and the other by sarafotoxins. The possible mediation of G-protein (s) in the induction by ET/SRTX receptors of PI-hydrolysis is discussed.
UR - http://www.scopus.com/inward/record.url?scp=0025030431&partnerID=8YFLogxK
U2 - 10.1016/0006-291X(90)90776-J
DO - 10.1016/0006-291X(90)90776-J
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AN - SCOPUS:0025030431
SN - 0006-291X
VL - 171
SP - 949
EP - 954
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 3
ER -
