Endothelin-1 receptors on the human placenta and fetal membranes: Evidence for different binding properties in pre-eclamptic pregnancies

E. Schiff*, R. Gabon, G. Ben-baruch, S. Mashiach, M. Sokolovsky

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Densities and affinities of tissue protein receptor sites for endothelin-1 in placental and fetal membranes of six preeclamptic and 16 normotensive women in the 36-41th week of gestation were determined by the use of a binding assay with [125I]endothelin-1. The mean maximal density of receptor sites (Bmax) was significantly higher in the placentas of the pre-eclamptic than of the normotensive women (905 ± 107 us. 539 ± 140fmollmg protein, p < 0.0001). No differences were found between the two groups with respect to the mean affinity (Kd) of placental receptors, or the mean Bmax and the mean Kd of fetal chorionic samples. In the normotensive group, there were no differences in mean placental Bmax values or in mean Kd values between women who went into spontaneous labor (whether delivered vaginally or abdominally) and those who were electively operated on prior to labor onset. No binding sites were detected in the fetal amniotic membranes of any of the women. Our results suggest that an increase in the maximal density of receptor sites to endothelin-1 in the placenta may play a role in the pathophysiology of pre-eclampsia by contributing to the placental insufficiency that characterizes this disorder.

Original languageEnglish
Pages (from-to)67-72
Number of pages6
JournalGynecological Endocrinology
Volume7
Issue number1
DOIs
StatePublished - 1993

Keywords

  • Binding Assay
  • Endothelin-1
  • Pre-eclampsia
  • Pregnancy-induced Hypertension

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