Endothelial dysfunction in venous pulmonary hypertension in the neonatal piglet

Alain Serraf*, Philippe Hervé, Carlos Labat, Guy Michel Mazmanian, Vincent de Montpreville, Claude Planché, Charles Brink

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


In a group of neonatal piglets an increase in pulmonary arterial pressure was obtained within 2 weeks after a partial mechanical obstruction of the left atrium by a balloon catheter. Mean pulmonary artery pressure in the hypertensive animals (n = 6) was 24 ± 2 mm Hg as compared (p < 0.01) with 15 ± 1 mm Hg in controls (n = 6) or 9 ± 2 mm Hg in sham-operated piglets (n = 6). Cardiac index was reduced in hypertensive versus control and sham groups: 0.15 ± 0.01 versus 0.32 ± 0.05 and 0.29 ± 0.04 L · min-1 · kg-1 (p < 0.05), respectively. There was no detectable difference on histologic examination in the pulmonary arteries between the three groups. Right ventricular hypertrophy was observed in the group with pulmonary hypertension. In hypertensive piglets, isolated conduit pulmonary arteries did not relax when stimulated with acetylcholine; they always relaxed to sodium nitroprusside. These data suggest that the first stages of perturbations reported during pulmonary venous hypertension occur at the level of the pulmonary vascular endothelium. This neonatal model of pulmonary hypertension is simple to perform and might be useful for further investigations.

Original languageEnglish
Pages (from-to)1155-1161
Number of pages7
JournalAnnals of Thoracic Surgery
Issue number5
StatePublished - May 1995
Externally publishedYes


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