TY - JOUR
T1 - Endometrial receptivity
T2 - The age-related decline in pregnancy rates and the effect of ovarian function
AU - Yaron, Y.
AU - Botchan, A.
AU - Amit, A.
AU - Kogosowski, A.
AU - Yovel, I.
AU - Lessing, J. B.
PY - 1993
Y1 - 1993
N2 - Objective: To assess the effect of age and ovarian function on endometrial receptivity. Design: Retrospective comparison between standard IVF and ovum donation in younger and older patients (<40 and ≥40 years of age, respectively). Patients: In standard IVF, there were 325 transfer cycles in older patients and 1,103 transfer cycles in younger ones. In ovum donation, there were 236 transfer cycles in older patients and 222 cycles in younger women. Ovum recipients were then redivided into two groups, according to ovarian function: ovarian failure group (219 cycles) and eugonadal group (239 cycles) in patients with retained ovarian function as manifested by regular menstrual cycles and normal gonadotropins. Results: In standard IVF, clinical pregnancy rates (PRs) were significantly lower in older patients (12.9% versus 23.8%, respectively). In ovum donation, clinical PRs were also significantly lower in older patients (21.2% versus 29.3%, respectively). A significantly higher clinical PR (31.1%) was noted in patients with ovarian failure, compared with both eugonadal patients undergoing ovum donation (19.7%) and standard IVF patients (21.3%). Conclusions: The decrease in endometrial receptivity with age is responsible for the higher rate of implantation failure in older women. Patients with nonfunctioning ovaries do better than eugonadal patients in ovum donation programs.
AB - Objective: To assess the effect of age and ovarian function on endometrial receptivity. Design: Retrospective comparison between standard IVF and ovum donation in younger and older patients (<40 and ≥40 years of age, respectively). Patients: In standard IVF, there were 325 transfer cycles in older patients and 1,103 transfer cycles in younger ones. In ovum donation, there were 236 transfer cycles in older patients and 222 cycles in younger women. Ovum recipients were then redivided into two groups, according to ovarian function: ovarian failure group (219 cycles) and eugonadal group (239 cycles) in patients with retained ovarian function as manifested by regular menstrual cycles and normal gonadotropins. Results: In standard IVF, clinical pregnancy rates (PRs) were significantly lower in older patients (12.9% versus 23.8%, respectively). In ovum donation, clinical PRs were also significantly lower in older patients (21.2% versus 29.3%, respectively). A significantly higher clinical PR (31.1%) was noted in patients with ovarian failure, compared with both eugonadal patients undergoing ovum donation (19.7%) and standard IVF patients (21.3%). Conclusions: The decrease in endometrial receptivity with age is responsible for the higher rate of implantation failure in older women. Patients with nonfunctioning ovaries do better than eugonadal patients in ovum donation programs.
KW - IVF
KW - Ovum donation
KW - endometrial receptivity
UR - http://www.scopus.com/inward/record.url?scp=0027171802&partnerID=8YFLogxK
U2 - 10.1016/S0015-0282(16)56104-4
DO - 10.1016/S0015-0282(16)56104-4
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???
AN - SCOPUS:0027171802
SN - 0015-0282
VL - 60
SP - 314
EP - 318
JO - Fertility and Sterility
JF - Fertility and Sterility
IS - 2
ER -