TY - JOUR
T1 - Endometrial changes with tamoxifen
T2 - Comparison between tamoxifen-treated and nontreated asymptomatic, postmenopausal breast cancer patients
AU - Cohen, Ilan
AU - Rosen, Doron J.D.
AU - Shapira, Jermia
AU - Cordoba, Mario
AU - Gilboa, Shlomo
AU - Altaras, Marco M.
AU - Yigael, Dror
AU - Beyth, Yoram
PY - 1994/2
Y1 - 1994/2
N2 - Endometrial thickness, as evaluated by vaginal ultrasonography, and endometrial histologic findings, as well as demographic characteristics, health habits, and risk factors for endometrial cancer, were compared between 93 asymptomatic postmenopausal breast cancer patients who had been on tamoxifen treatment and 20 patients who had not. The mean ultrasonographic endometrial thickness in the women on tamoxifen treatment was 13.1 ± 10.4 mm, which was significantly thicker than the 4.0 ± 3.2 mm found in the nontreated women (P = 0.001). The frequency of endometrial pathological findings was remarkably high (35.5%) among the tamoxifen-treated patients, compared with nontreated patients (20.0%), with a P value of 0.058 and an odd ratio of 4.6. Thus, it is suggested that the remarkably high prevalence of pathological endometrial changes was due to the continuous and unopposed exposure of the endometrium to tamoxifen.
AB - Endometrial thickness, as evaluated by vaginal ultrasonography, and endometrial histologic findings, as well as demographic characteristics, health habits, and risk factors for endometrial cancer, were compared between 93 asymptomatic postmenopausal breast cancer patients who had been on tamoxifen treatment and 20 patients who had not. The mean ultrasonographic endometrial thickness in the women on tamoxifen treatment was 13.1 ± 10.4 mm, which was significantly thicker than the 4.0 ± 3.2 mm found in the nontreated women (P = 0.001). The frequency of endometrial pathological findings was remarkably high (35.5%) among the tamoxifen-treated patients, compared with nontreated patients (20.0%), with a P value of 0.058 and an odd ratio of 4.6. Thus, it is suggested that the remarkably high prevalence of pathological endometrial changes was due to the continuous and unopposed exposure of the endometrium to tamoxifen.
UR - http://www.scopus.com/inward/record.url?scp=0028158119&partnerID=8YFLogxK
U2 - 10.1006/gyno.1994.1029
DO - 10.1006/gyno.1994.1029
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AN - SCOPUS:0028158119
SN - 0090-8258
VL - 52
SP - 185
EP - 190
JO - Gynecologic Oncology
JF - Gynecologic Oncology
IS - 2
ER -
