Endometrial cancers in postmenopausal breast cancer patients with tamoxifen treatment

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To evaluate possible predicting factors for endometrial cancer in postmenopausal breast cancer patients with tamoxifen treatment, we compared various clinical features between 12 postmenopausal breast cancer tamoxifen- treated patients with endometrial cancer and a control group of 261 otherwise similar patients without this endometrial pathology. These comparisons were based on a long-term prospective follow-up. Several clinical factors such as longer duration of breast disease, older patient age, lower frequency of chemotherapy administration, and higher frequency of postmenopausal bleeding were found among the tamoxifen-treated patients with endometrial cancers, and were significantly different when compared to the control group. Only eight (66.7%) had postmenopausal bleeding, and a preoperative diagnosis of endometrial cancer was made in only six (50.0%). When considering postmenopausal bleeding as a marker for endometrial cancer in the study patients, sensitivity was 67% and specificity was 98%.

Original languageEnglish
Pages (from-to)304-309
Number of pages6
JournalInternational Journal of Gynecological Pathology
Issue number4
StatePublished - Oct 1999


  • Breast cancer
  • Endometrial carcinoma
  • Menopause
  • Tamoxifen


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