Endometrial cancer presentation is associated with social determinants of health in a public healthcare system: A population-based cohort study

Limor Helpman*, Greg R. Pond, Lorraine Elit, Laura N. Anderson, Hsien Seow

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Objective: Delay in diagnosis of endometrial cancer may be associated with disease progression and impact management and outcomes. Social and cultural barriers influence recognition of symptoms and self-advocacy in seeking care. Associations between social determinants of health (SDH) and disease presentation have been shown in some settings. Our objective was to investigate these in Ontario's universal access system. Methods: Endometrial cancer patients in Ontario diagnosed 2009–2017 were identified, and clinical, social and demographic information extracted from administrative databases using ICES (Institute of Evaluative Sciences) algorithms. SDH were quantified using previously validated marginalization indices for material deprivation, residential instability and ethnic concentration. Associations between SDH and disease stage were explored using logistic regression. Results: 20,228 patients were identified. 73% of cancers were confined to the uterus. Stage distribution differed across marginalization quintiles (p < 0.001) with advanced disease found more frequently in highly marginalized patients: 29% vs. 25% (p < 0.001) for material deprivation, OR = 1.06/quintile (CI, 1.03–1.09); 29% vs. 24% (p < 0.001) for ethnic concentration, OR = 1.05/quintile (CI, 1.03–1.08); 30% vs. 27% (p < 0.001) for residential instability, OR = 1.02/quintile (CI, 1.0–1.05). Marginalization was persistently associated with advanced disease on multivariable analysis adjusted for age, comorbidity score, obesity and disease histology (OR = 1.05/quintile, CI 1.01–1.10, p = 0.03). Conclusions: Socioeconomic marginalization is associated with advanced disease at presentation among endometrial cancer patients in Ontario. Mediators of this association are likely multifactorial, and need to be further investigated in order to create opportunities for improved patient education and advocacy, redistribution of resources and the promotion of health equity.

Original languageEnglish
Pages (from-to)130-136
Number of pages7
JournalGynecologic Oncology
Issue number1
StatePublished - Jul 2020
Externally publishedYes


  • Endometrial cancer
  • Social determinants of health
  • Uterine cancer


Dive into the research topics of 'Endometrial cancer presentation is associated with social determinants of health in a public healthcare system: A population-based cohort study'. Together they form a unique fingerprint.

Cite this