Endogenous opioids mediate ECS-induced catalepsy at supraspinal levels

Hanan Frenk, Barry E. Stein

Research output: Contribution to journalArticlepeer-review

Abstract

Several lines of evidence point to the involvement of endogenous opioids in the mediation of electroconvulsive shock (ECS)-induced catalepsy. Although the site of action of these agents has not yet been determined, the spinal cord has been a likely candidate. Using intrathecal and systemic administrations of morphine and naltrexone, the present experiments were designed to test this possibility directly. The data obtained were consistent with the involvement of endogenous opioids in mediating ECS-induced catalepsy, but it was clearly evident that the site of action of these agents was at supraspinal, not spinal levels.

Original languageEnglish
Pages (from-to)109-112
Number of pages4
JournalBrain Research
Volume303
Issue number1
DOIs
StatePublished - 11 Jun 1984
Externally publishedYes

Keywords

  • catalepsy
  • electroconvulsive shock
  • endogenous opioids
  • postictal behavioral depression

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