Endogenous Glucocorticoid Signaling Regulates CD8+ T Cell Differentiation and Development of Dysfunction in the Tumor Microenvironment

Nandini Acharya, Asaf Madi, Huiyuan Zhang, Max Klapholz, Giulia Escobar, Shai Dulberg, Elena Christian, Michelle Ferreira, Karen O. Dixon, Geoffrey Fell, Katherine Tooley, Davide Mangani, Junrong Xia, Meromit Singer, Marcus Bosenberg, Donna Neuberg, Orit Rozenblatt-Rosen, Aviv Regev, Vijay K. Kuchroo, Ana C. Anderson

Research output: Contribution to journalArticlepeer-review

Abstract

Acharya et al. uncover a gradient of increasing glucocorticoid signaling from naïve to dysfunctional CD8+ tumor-infiltrating lymphocytes. This gradient regulates effector transition and development of dysfunction. Glucocorticoid is produced locally by tumor-associated monocyte-macrophage lineage cells, and presence of active glucocorticoid signaling associates with poor response to immune checkpoint blockade.

Original languageEnglish
Pages (from-to)658-671.e6
JournalImmunity
Volume53
Issue number3
DOIs
StatePublished - 15 Sep 2020

Keywords

  • CD8 T cell
  • Nr3c1
  • TCF-1
  • cancer
  • dysfunction
  • exhaustion
  • glucocorticoid
  • immune checkpoint blockade
  • steroid
  • tumor-associated macrophages

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