Abstract
A retrospective analysis of ovarian hyperstimulation syndrome in high responders undergoing in-vitro fertilization (IVF) is presented. High responders were defined as having > 20 follicles and serum oestradiol > 3000 pg/ml after treatment with human menopausal gonadotrophin. Of the initial 30 IVF cycles in high responders, 23 developed a moderate-to-severe ovarian hyperstimulation syndrome (76.7%). Subsequently, 15 other IVF cycles in high responders were combined with a repeated aspiration of ovarian follicles and corpus luteum cysts just prior to embryo transfer. Only three patients (20%) developed a moderate ovarian hyperstimulation syndrome (P = 0.0004). We conclude that repeated follicular aspiration is safe and results in a significant reduction in the incidence and severity of this condition in high responders undergoing IVF.
Original language | English |
---|---|
Pages (from-to) | 1184-1186 |
Number of pages | 3 |
Journal | Human Reproduction |
Volume | 8 |
Issue number | 8 |
DOIs | |
State | Published - Aug 1993 |
Keywords
- In-vitro fertilization
- Ovarian hyperstimulation syndrome
- Ovulation induction
- Repeated aspiration