Endocrinology: Repeated aspiration of ovarian follicles and early corpus luteum cysts in an in-vitro fertilization programme reduces the risk of ovarian hyperstimulation syndrome in high responders

A. Amit, Y. Yaron, I. Yovel, M. R. Peyser, M. P. David, A. Botchan, J. B. Lessing*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

A retrospective analysis of ovarian hyperstimulation syndrome in high responders undergoing in-vitro fertilization (IVF) is presented. High responders were defined as having > 20 follicles and serum oestradiol > 3000 pg/ml after treatment with human menopausal gonadotrophin. Of the initial 30 IVF cycles in high responders, 23 developed a moderate-to-severe ovarian hyperstimulation syndrome (76.7%). Subsequently, 15 other IVF cycles in high responders were combined with a repeated aspiration of ovarian follicles and corpus luteum cysts just prior to embryo transfer. Only three patients (20%) developed a moderate ovarian hyperstimulation syndrome (P = 0.0004). We conclude that repeated follicular aspiration is safe and results in a significant reduction in the incidence and severity of this condition in high responders undergoing IVF.

Original languageEnglish
Pages (from-to)1184-1186
Number of pages3
JournalHuman Reproduction
Volume8
Issue number8
DOIs
StatePublished - Aug 1993

Keywords

  • In-vitro fertilization
  • Ovarian hyperstimulation syndrome
  • Ovulation induction
  • Repeated aspiration

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