Endocrinological basis of hot flushes

D. Bider, S. Mashiach, D. M. Serr, Z. Ben-Rafael*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review


Hot flushes are frequent among women during natural, surgical, or pharmacological menopause. The available data suggest the involvement of estrogens, progestins, catecholestrogens, catecholamines, dopamine, endorphins, prostaglandins, luteinizing hormone (LH) and luteinizing hormone-releasing hormone (LH-RH) in the pathogenesis of flushes. At present the estrogen withdrawal and pulsatile luteinizing hormone (LH) secretion theories are most commonly accepted for explaining the development of this symptom. The use of LH-RH agonists offers an opportunity to focus on the probable origin and region that regulate the events of this phenomena, since the administration of this drug is associated with hot flushes, in spite of low gonadotropins and normal estrogen levels. Current data may suggest that the origin of this neurovegetative symptom lies in the hypothalamus.

Original languageEnglish
Pages (from-to)495-499
Number of pages5
JournalObstetrical and Gynecological Survey
Issue number7
StatePublished - Jul 1989
Externally publishedYes


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