TY - JOUR
T1 - Endocrine studies of the ovulatory disturbances in Wilson's disease (hepatolenticular degeneration)
AU - Kaushansky, A.
AU - Frydman, M.
AU - Kaufman, H.
AU - Homburg, R.
PY - 1987
Y1 - 1987
N2 - Women with Wilson's disease may have severe oligomenorrhea or amenorrhea whose cause is unknown. The endocrine profile of four such cases was investigated by measuring basal values and the response to dynamic tests of hypothalamic, pituitary, thyroid, and adrenal function, which all proved normal. Ovarian function was disturbed, as witnessed by low estradiol, high total testosterone (T) levels with normal free T, and mildly elevated androstenedione. An interference of ovarian follicular aromatase activity possibly due to copper intoxication could explain these findings as the cause of the ovulatory disturbances of Wilson's disease.
AB - Women with Wilson's disease may have severe oligomenorrhea or amenorrhea whose cause is unknown. The endocrine profile of four such cases was investigated by measuring basal values and the response to dynamic tests of hypothalamic, pituitary, thyroid, and adrenal function, which all proved normal. Ovarian function was disturbed, as witnessed by low estradiol, high total testosterone (T) levels with normal free T, and mildly elevated androstenedione. An interference of ovarian follicular aromatase activity possibly due to copper intoxication could explain these findings as the cause of the ovulatory disturbances of Wilson's disease.
UR - http://www.scopus.com/inward/record.url?scp=0023110671&partnerID=8YFLogxK
U2 - 10.1016/S0015-0282(16)50004-1
DO - 10.1016/S0015-0282(16)50004-1
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AN - SCOPUS:0023110671
SN - 0015-0282
VL - 47
SP - 270
EP - 273
JO - Fertility and Sterility
JF - Fertility and Sterility
IS - 2
ER -