Enantioselective synthesis of indole derivatives by Rh/Pd relay catalysis and their anti-inflammatory evaluation

Sifeng Li; Zihao Wang; Haitao Xiao; Zhaoxiang Bian; Jun Wang

doi:10.1039/d0cc03158e

Enantioselective synthesis of indole derivatives by Rh/Pd relay catalysis and their anti-inflammatory evaluation

Sifeng Li, Zihao Wang, Haitao Xiao, Zhaoxiang Bian, Jun Wang

Research output: Contribution to journal › Article › peer-review

Abstract

An efficient Rh/Pd relay catalyzed intermolecular and cascade intramolecular hydroamination for the synthesis of exclusive trans 1-indolyl dihydronaphthalenols (up to 88% yield, 99% ee) is described under mild conditions. Moreover, the in silico and in vitro screening showed that the novel 1-indolyl dihydronaphthalenol products are potent lead compounds for treating inflammation disease.

Original language	English
Pages (from-to)	7573-7576
Number of pages	4
Journal	Chemical Communications
Volume	56
Issue number	55
DOIs	https://doi.org/10.1039/d0cc03158e
State	Published - 14 Jul 2020
Externally published	Yes

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abstract = "An efficient Rh/Pd relay catalyzed intermolecular and cascade intramolecular hydroamination for the synthesis of exclusive trans 1-indolyl dihydronaphthalenols (up to 88% yield, 99% ee) is described under mild conditions. Moreover, the in silico and in vitro screening showed that the novel 1-indolyl dihydronaphthalenol products are potent lead compounds for treating inflammation disease.",

author = "Sifeng Li and Zihao Wang and Haitao Xiao and Zhaoxiang Bian and Jun Wang",

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AU - Li, Sifeng

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AU - Wang, Jun

PY - 2020/7/14

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AB - An efficient Rh/Pd relay catalyzed intermolecular and cascade intramolecular hydroamination for the synthesis of exclusive trans 1-indolyl dihydronaphthalenols (up to 88% yield, 99% ee) is described under mild conditions. Moreover, the in silico and in vitro screening showed that the novel 1-indolyl dihydronaphthalenol products are potent lead compounds for treating inflammation disease.

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Enantioselective synthesis of indole derivatives by Rh/Pd relay catalysis and their anti-inflammatory evaluation

Abstract

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