Enantioselective synthesis of indole derivatives by Rh/Pd relay catalysis and their anti-inflammatory evaluation

Sifeng Li, Zihao Wang, Haitao Xiao, Zhaoxiang Bian, Jun Wang

Research output: Contribution to journalArticlepeer-review

Abstract

An efficient Rh/Pd relay catalyzed intermolecular and cascade intramolecular hydroamination for the synthesis of exclusive trans 1-indolyl dihydronaphthalenols (up to 88% yield, 99% ee) is described under mild conditions. Moreover, the in silico and in vitro screening showed that the novel 1-indolyl dihydronaphthalenol products are potent lead compounds for treating inflammation disease.

Original languageEnglish
Pages (from-to)7573-7576
Number of pages4
JournalChemical Communications
Volume56
Issue number55
DOIs
StatePublished - 14 Jul 2020
Externally publishedYes

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