Enabling magnetic resonance imaging of hollow-core microstructured optical fibers via nanocomposite coating

Roman E. Noskov, Anastasia A. Zanishevskaya, Andrey A. Shuvalov, Sergei V. German, Olga A. Inozemtseva, Taras P. Kochergin, Ekaterina N. Lazareva, Valery V. Tuchin, Pavel Ginzburg, Julia S. Skibina, Dmitry A. Gorin

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Optical fibers are widely used in bioimaging systems as flexible endoscopes that are capable of low-invasive penetration inside hollow tissue cavities. Here, we report on the technique that allows magnetic resonance imaging (MRI) of hollow-core microstructured fibers (HC-MFs), which paves the way for combing MRI and optical bioimaging. Our approach is based on layer-by-layer assembly of oppositely charged polyelectrolytes and magnetite nanoparticles on the inner core surface of HC-MFs. Incorporation of magnetite nanoparticles into polyelectrolyte layers renders HC-MFs visible for MRI and induces the red-shift in their transmission spectra. Specifically, the transmission shifts up to 60 nm have been revealed for the several-layers composite coating, along with the high-quality contrast of HC-MFs in MRI scans. Our results shed light on marrying fiber-based endoscopy with MRI to open novel possibilities for minimally invasive clinical diagnostics and surgical procedures in vivo.

Original languageEnglish
Pages (from-to)9868-9878
Number of pages11
JournalOptics Express
Volume27
Issue number7
DOIs
StatePublished - 1 Apr 2019

Funding

FundersFunder number
Russian Federation Governmental
Horizon 2020 Framework Programme802279
European Research Council
Russian Foundation for Basic Research18-29-08046
Tel Aviv University
PAZY Foundation01021248

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