TY - JOUR
T1 - Empowering Regulatory T Cells in Autoimmunity
AU - Kasper, Isaac R.
AU - Apostolidis, Sokratis A.
AU - Sharabi, Amir
AU - Tsokos, George C.
N1 - Publisher Copyright:
© 2016 Elsevier Ltd
PY - 2016/9/1
Y1 - 2016/9/1
N2 - Regulatory T cells (Tregs) are capable of dampening immune-mediated inflammation and avert the destructive effects of uncontrolled inflammation. Distinct molecules and pathways, including various transcription factors, phosphatases, and kinases, impact the ability of Tregs to function as negative regulators of the immune response, and are presumably amenable to therapeutic manipulation. Here, we discuss recently identified molecular networks and the therapeutic potential for treating autoimmune diseases.
AB - Regulatory T cells (Tregs) are capable of dampening immune-mediated inflammation and avert the destructive effects of uncontrolled inflammation. Distinct molecules and pathways, including various transcription factors, phosphatases, and kinases, impact the ability of Tregs to function as negative regulators of the immune response, and are presumably amenable to therapeutic manipulation. Here, we discuss recently identified molecular networks and the therapeutic potential for treating autoimmune diseases.
UR - http://www.scopus.com/inward/record.url?scp=84990966815&partnerID=8YFLogxK
U2 - 10.1016/j.molmed.2016.07.003
DO - 10.1016/j.molmed.2016.07.003
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C2 - 27461103
AN - SCOPUS:84990966815
SN - 1471-4914
VL - 22
SP - 784
EP - 797
JO - Trends in Molecular Medicine
JF - Trends in Molecular Medicine
IS - 9
ER -