Empowering Regulatory T Cells in Autoimmunity

Isaac R. Kasper*, Sokratis A. Apostolidis, Amir Sharabi, George C. Tsokos

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

Regulatory T cells (Tregs) are capable of dampening immune-mediated inflammation and avert the destructive effects of uncontrolled inflammation. Distinct molecules and pathways, including various transcription factors, phosphatases, and kinases, impact the ability of Tregs to function as negative regulators of the immune response, and are presumably amenable to therapeutic manipulation. Here, we discuss recently identified molecular networks and the therapeutic potential for treating autoimmune diseases.

Original languageEnglish
Pages (from-to)784-797
Number of pages14
JournalTrends in Molecular Medicine
Volume22
Issue number9
DOIs
StatePublished - 1 Sep 2016

Funding

FundersFunder number
National Institutes of HealthT32AI074549
National Institute of Allergy and Infectious DiseasesR01AI068787

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