Emerging Roles for Eosinophils in the Tumor Microenvironment

Hadar Reichman, Danielle Karo-Atar, Ariel Munitz*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

Eosinophils are evolutionary conserved cells largely studied in the context of allergy. Although eosinophils were first described in tumors more than 120 years ago, their roles in cancer are often overlooked. This is puzzling given their potent immune modulatory, cytotoxic, and/or tissue repair capabilities, and recent studies demonstrating key roles for eosinophils in contexts far beyond their ‘classical’ field (e.g., metabolism, thermogenesis, and tissue regeneration). Recent data suggest that this frequently ignored cell is emerging as a potent immune effector and immune modulator in the tumor microenvironment. This review discusses the relevance of eosinophils to tumorigenesis and the potential to harness their function in cancer therapies.

Original languageEnglish
Pages (from-to)664-675
Number of pages12
JournalTrends in Cancer
Volume2
Issue number11
DOIs
StatePublished - 1 Nov 2016

Funding

FundersFunder number
Israel Cancer Research Foundation
Israel Ministry of Health3-10117
US–Israel Bi-national Science Foundation2011244
Israel Cancer Association20150002
Israel Science Foundation955/11
Tel Aviv University
Varda and Boaz Dotan Research Center for Hemato-Oncology Research, Tel Aviv University

    Keywords

    • cancer
    • cytotoxicity
    • eosinophils
    • eotaxin
    • inflammation
    • interleukin-5
    • tumor microenvironment

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