TY - JOUR
T1 - Emergency use of intravenous phytonadione (Vitamin K1) for treatment of severe bleeding in a child with chronic cholestasis
AU - Glatstein, Miguel
AU - Idan-Prusak, Dafna
AU - Yahav, Aiala
AU - Ovental, Amit
AU - Rimon, Ayelet
AU - Scolnik, Dennis
N1 - Publisher Copyright:
© 2011 Lippincott Williams & Wilkins.
PY - 2013
Y1 - 2013
N2 - We present a 5-year-old boy with multiple hematomas associated with chronic cholestasis. A week before admission he suffered minor trauma at day care. The next day he complained of trunk and limb pain and orthopedic consultation, including leg X-rays, revealed no abnormalities. Over the next 5 days multiple hematomas developed over his body and increased in size. In the Emergency Department he was in pain and looked sick but alert. He had fever and tachycardia, with normal blood pressure and respiratory status and physical examination showed several hematomas on the legs, which increased in size during observation in the Emergency Department over 2 hours. Blood work revealed multiple coagulation abnormalities, and International Normalized Ratio was 12. Intravenous phytonadione (vitamin K1) was immediately administered with normalization of coagulation abnormalities within 1 hour and the hematomas stopped growing in size. In addition to missing follow-up with the Pediatric Gastroenterology Department, social service agency inquiry found he had not taken his medications for several months. With severe abnormal bleeding and hepatic disease, intravenous vitamin K1 may be lifesaving, even before obtaining confirmatory blood work, fresh-frozen plasma, or blood transfusion.
AB - We present a 5-year-old boy with multiple hematomas associated with chronic cholestasis. A week before admission he suffered minor trauma at day care. The next day he complained of trunk and limb pain and orthopedic consultation, including leg X-rays, revealed no abnormalities. Over the next 5 days multiple hematomas developed over his body and increased in size. In the Emergency Department he was in pain and looked sick but alert. He had fever and tachycardia, with normal blood pressure and respiratory status and physical examination showed several hematomas on the legs, which increased in size during observation in the Emergency Department over 2 hours. Blood work revealed multiple coagulation abnormalities, and International Normalized Ratio was 12. Intravenous phytonadione (vitamin K1) was immediately administered with normalization of coagulation abnormalities within 1 hour and the hematomas stopped growing in size. In addition to missing follow-up with the Pediatric Gastroenterology Department, social service agency inquiry found he had not taken his medications for several months. With severe abnormal bleeding and hepatic disease, intravenous vitamin K1 may be lifesaving, even before obtaining confirmatory blood work, fresh-frozen plasma, or blood transfusion.
KW - Bleeding
KW - Cholestasis
KW - Phytonadione
KW - Vitamin K
UR - http://www.scopus.com/inward/record.url?scp=84904379134&partnerID=8YFLogxK
U2 - 10.1097/MJT.0b013e318217a5c0
DO - 10.1097/MJT.0b013e318217a5c0
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C2 - 21642829
AN - SCOPUS:84904379134
SN - 1075-2765
VL - 20
SP - e733-e735
JO - American Journal of Therapeutics
JF - American Journal of Therapeutics
IS - 6
ER -