Emergence of W272C substitution in Hmg1 in a triazole-resistant isolate of aspergillus fumigatus from a Chinese patient with chronic cavitary pulmonary aspergillosis

Tianyu Liang, Xinyu Yang, Ruoyu Li, Ence Yang, Qiqi Wang, Nir Osherov, Wei Chen, Zhe Wan, Wei Liu*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Recently, mutations in the 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA) reductase gene (hmg1) have been identified to be associated with triazole resistance in Aspergillus fumigatus. Here, we describe the first case of the G929C mutation in the hmg1 gene, leading to the W272C amino acid substitution, in a triazole-resistant isolate of A. fumigatus recovered from a chronic cavitary pulmonary aspergillosis patient who failed voriconazole therapy in China.

Original languageEnglish
Article numbere00263-21
JournalAntimicrobial Agents and Chemotherapy
Volume65
Issue number7
DOIs
StatePublished - Jul 2021

Funding

FundersFunder number
Natural Science Foundation of Guangxi Province of China project Guangxi Innovation Research Team for Fungal Infectious Diseases Prevention and Treatment2020GXNSFGA238001
National Natural Science Foundation of China81971912, 81861148028, 81671990

    Keywords

    • Aspergillus fumigatus
    • Hmg1 mutation
    • Triazole resistance
    • W272C substitution

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