Emergence of the concept of platelet reactivity monitoring of response to thienopyridines

L. Bonello; A. De Labriolle; M. Scheinowitz; G. Lemesle; P. Roy; D. H. Steinberg; T. L. Pinto Slottow; R. Pakala; A. D. Pichard; P. Barragan; L. Camoin-Jau; F. Dignat-George; F. Paganelli; R. Waksman

doi:10.1136/hrt.2008.152660

Emergence of the concept of platelet reactivity monitoring of response to thienopyridines

L. Bonello, A. De Labriolle, M. Scheinowitz, G. Lemesle, P. Roy, D. H. Steinberg, T. L. Pinto Slottow, R. Pakala, A. D. Pichard, P. Barragan, L. Camoin-Jau, F. Dignat-George, F. Paganelli, R. Waksman^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

18 Scopus citations

Abstract

Clinical trials have demonstrated the beneficial impact of clopidogrel in preventing major adverse cardiovascular events (MACE), particularly in patients undergoing percutaneous coronary intervention (PCI). The concept of biological clopidogrel resistance emerged with the finding of persistent platelet activation despite clopidogrel therapy in some patients. Further, a link between biological clopidogrel resistance and thrombotic recurrence after PCI was observed and a threshold of platelet reactivity (PR) for thrombotic events was suggested. Consistently, in recent trials, enhanced PR inhibition translated into a reduction in the rate of MACE after PCI. This review aims to present the emergence of the concept of PR monitoring in patients undergoing PCI following recent advances in this field.

Original language	English
Pages (from-to)	1214-1219
Number of pages	6
Journal	Heart
Volume	95
Issue number	15
DOIs	https://doi.org/10.1136/hrt.2008.152660
State	Published - Aug 2009
Externally published	Yes

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Bonello, L., De Labriolle, A., Scheinowitz, M., Lemesle, G., Roy, P., Steinberg, D. H., Pinto Slottow, T. L., Pakala, R., Pichard, A. D., Barragan, P., Camoin-Jau, L., Dignat-George, F., Paganelli, F., & Waksman, R. (2009). Emergence of the concept of platelet reactivity monitoring of response to thienopyridines. Heart, 95(15), 1214-1219. https://doi.org/10.1136/hrt.2008.152660

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title = "Emergence of the concept of platelet reactivity monitoring of response to thienopyridines",

abstract = "Clinical trials have demonstrated the beneficial impact of clopidogrel in preventing major adverse cardiovascular events (MACE), particularly in patients undergoing percutaneous coronary intervention (PCI). The concept of biological clopidogrel resistance emerged with the finding of persistent platelet activation despite clopidogrel therapy in some patients. Further, a link between biological clopidogrel resistance and thrombotic recurrence after PCI was observed and a threshold of platelet reactivity (PR) for thrombotic events was suggested. Consistently, in recent trials, enhanced PR inhibition translated into a reduction in the rate of MACE after PCI. This review aims to present the emergence of the concept of PR monitoring in patients undergoing PCI following recent advances in this field.",

author = "L. Bonello and {De Labriolle}, A. and M. Scheinowitz and G. Lemesle and P. Roy and Steinberg, {D. H.} and {Pinto Slottow}, {T. L.} and R. Pakala and Pichard, {A. D.} and P. Barragan and L. Camoin-Jau and F. Dignat-George and F. Paganelli and R. Waksman",

year = "2009",

month = aug,

doi = "10.1136/hrt.2008.152660",

language = "אנגלית",

volume = "95",

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Bonello, L, De Labriolle, A, Scheinowitz, M, Lemesle, G, Roy, P, Steinberg, DH, Pinto Slottow, TL, Pakala, R, Pichard, AD, Barragan, P, Camoin-Jau, L, Dignat-George, F, Paganelli, F & Waksman, R 2009, 'Emergence of the concept of platelet reactivity monitoring of response to thienopyridines', Heart, vol. 95, no. 15, pp. 1214-1219. https://doi.org/10.1136/hrt.2008.152660

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T1 - Emergence of the concept of platelet reactivity monitoring of response to thienopyridines

AU - Bonello, L.

AU - De Labriolle, A.

AU - Scheinowitz, M.

AU - Lemesle, G.

AU - Roy, P.

AU - Steinberg, D. H.

AU - Pinto Slottow, T. L.

AU - Pakala, R.

AU - Pichard, A. D.

AU - Barragan, P.

AU - Camoin-Jau, L.

AU - Dignat-George, F.

AU - Paganelli, F.

AU - Waksman, R.

PY - 2009/8

Y1 - 2009/8

N2 - Clinical trials have demonstrated the beneficial impact of clopidogrel in preventing major adverse cardiovascular events (MACE), particularly in patients undergoing percutaneous coronary intervention (PCI). The concept of biological clopidogrel resistance emerged with the finding of persistent platelet activation despite clopidogrel therapy in some patients. Further, a link between biological clopidogrel resistance and thrombotic recurrence after PCI was observed and a threshold of platelet reactivity (PR) for thrombotic events was suggested. Consistently, in recent trials, enhanced PR inhibition translated into a reduction in the rate of MACE after PCI. This review aims to present the emergence of the concept of PR monitoring in patients undergoing PCI following recent advances in this field.

AB - Clinical trials have demonstrated the beneficial impact of clopidogrel in preventing major adverse cardiovascular events (MACE), particularly in patients undergoing percutaneous coronary intervention (PCI). The concept of biological clopidogrel resistance emerged with the finding of persistent platelet activation despite clopidogrel therapy in some patients. Further, a link between biological clopidogrel resistance and thrombotic recurrence after PCI was observed and a threshold of platelet reactivity (PR) for thrombotic events was suggested. Consistently, in recent trials, enhanced PR inhibition translated into a reduction in the rate of MACE after PCI. This review aims to present the emergence of the concept of PR monitoring in patients undergoing PCI following recent advances in this field.

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JO - Heart

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Emergence of the concept of platelet reactivity monitoring of response to thienopyridines

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