Emergence of obsessive-compulsive symptoms and tics during clozapine withdrawal

Michael Poyurovsky; Yosef Bergman; David Shoshani; Michael Schneidman; Abraham Weizman

Emergence of obsessive-compulsive symptoms and tics during clozapine withdrawal

Michael Poyurovsky, Yosef Bergman, David Shoshani, Michael Schneidman, Abraham Weizman^*

^*Corresponding author for this work

Clinical Departments

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

Treatment with clozapine may be associated with the appearance of obsessive-compulsive (OC) symptoms in up to 10% of schizophrenic patients. We present the first report of the emergence of de novo OC symptoms during clozapine withdrawal in two schizophrenic patients, associated in one with Tourette's syndrome-like tics. Resumption of clozapine led to the complete disappearance of the OC symptoms and a substantial alleviation of the tics. It is suggested that an imbalance between the dopamine and serotonin systems may account for this complication.

Original language	English
Pages (from-to)	97-100
Number of pages	4
Journal	Clinical Neuropharmacology
Volume	21
Issue number	2
State	Published - 1998

Keywords

Clozapine
Compulsive symptoms
Dopamine
Obsessive
Schizophrenia
Serotonin
Tourette's syndrome

Cite this

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title = "Emergence of obsessive-compulsive symptoms and tics during clozapine withdrawal",

abstract = "Treatment with clozapine may be associated with the appearance of obsessive-compulsive (OC) symptoms in up to 10% of schizophrenic patients. We present the first report of the emergence of de novo OC symptoms during clozapine withdrawal in two schizophrenic patients, associated in one with Tourette's syndrome-like tics. Resumption of clozapine led to the complete disappearance of the OC symptoms and a substantial alleviation of the tics. It is suggested that an imbalance between the dopamine and serotonin systems may account for this complication.",

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author = "Michael Poyurovsky and Yosef Bergman and David Shoshani and Michael Schneidman and Abraham Weizman",

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AU - Poyurovsky, Michael

AU - Bergman, Yosef

AU - Shoshani, David

AU - Schneidman, Michael

AU - Weizman, Abraham

PY - 1998

Y1 - 1998

N2 - Treatment with clozapine may be associated with the appearance of obsessive-compulsive (OC) symptoms in up to 10% of schizophrenic patients. We present the first report of the emergence of de novo OC symptoms during clozapine withdrawal in two schizophrenic patients, associated in one with Tourette's syndrome-like tics. Resumption of clozapine led to the complete disappearance of the OC symptoms and a substantial alleviation of the tics. It is suggested that an imbalance between the dopamine and serotonin systems may account for this complication.

AB - Treatment with clozapine may be associated with the appearance of obsessive-compulsive (OC) symptoms in up to 10% of schizophrenic patients. We present the first report of the emergence of de novo OC symptoms during clozapine withdrawal in two schizophrenic patients, associated in one with Tourette's syndrome-like tics. Resumption of clozapine led to the complete disappearance of the OC symptoms and a substantial alleviation of the tics. It is suggested that an imbalance between the dopamine and serotonin systems may account for this complication.

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KW - Compulsive symptoms

KW - Dopamine

KW - Obsessive

KW - Schizophrenia

KW - Serotonin

KW - Tourette's syndrome

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JO - Clinical Neuropharmacology

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Emergence of obsessive-compulsive symptoms and tics during clozapine withdrawal

Abstract

Keywords

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