Emergence of KPC-2 and KPC-3 in carbapenem-resistant Klebsiella pneumoniae strains in an Israeli hospital

Azita Leavitt, Shiri Navon-Venezia, Inna Chmelnitsky, Mitchell J. Schwaber, Yehuda Carmeli

Research output: Contribution to journalArticlepeer-review

Abstract

Carbapenem resistance due to KPC has rarely been observed outside the United States. We noticed a sharp increase in carbapenem-resistant Klebsiella pneumoniae strains possessing KPC in Tel Aviv Medical Center from 2004 to 2006. Sixty percent of the isolates belonged to a single clone susceptible only to gentamicin and colistin and carried the blaKPC-3 gene, while almost all other clones carried the blaKPC-2 gene. This rapid dissemination of KPC outside the United States is worrisome.

Original languageEnglish
Pages (from-to)3026-3029
Number of pages4
JournalAntimicrobial Agents and Chemotherapy
Volume51
Issue number8
DOIs
StatePublished - Aug 2007
Externally publishedYes

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