Emergence of genetically linked vaccine-originated poliovirus type 2 in the absence of oral polio vaccine, Jerusalem, April to July 2022

Neta S. Zuckerman; Itay Bar-Or; Danit Sofer; Efrat Bucris; Hagar Morad; Lester M. Shulman; Nofar Levi; Leah Weiss; Irina Aguvaev; Zvi Cohen; Klil Kestin; Rinat Vasserman; Michal Elul; Ilana S. Fratty; Miranda Geva; Marina Wax; Oran Erster; Ruth Yishai; Lior Hecht-Sagie; Sharon Alroy-Preis; Ella Mendelson; Merav Weil

doi:10.2807/1560-7917.ES.2022.27.37.2200694

Emergence of genetically linked vaccine-originated poliovirus type 2 in the absence of oral polio vaccine, Jerusalem, April to July 2022

Neta S. Zuckerman, Itay Bar-Or, Danit Sofer, Efrat Bucris, Hagar Morad, Lester M. Shulman, Nofar Levi, Leah Weiss, Irina Aguvaev, Zvi Cohen, Klil Kestin, Rinat Vasserman, Michal Elul, Ilana S. Fratty, Miranda Geva, Marina Wax, Oran Erster, Ruth Yishai, Lior Hecht-Sagie, Sharon Alroy-PreisElla Mendelson, Merav Weil

School of Public Health

Research output: Contribution to journal › Article › peer-review

Abstract

We report an emergence and increase in poliovirus type 2 detection via routine wastewater surveillance in three non-overlapping regions in the Jerusalem region, Israel, between April and July 2022. Sequencing showed genetic linkage among isolates and accumulation of mutations over time, with two isolates defined as vaccine-derived polioviruses (VDPV). This demonstrates the emergence and potential circulation of type 2 VDPV in a high-income country with high vaccine coverage and underscores the importance of routine wastewater surveillance during the polio eradication.

Original language	English
Journal	Eurosurveillance
Volume	27
Issue number	37
DOIs	https://doi.org/10.2807/1560-7917.ES.2022.27.37.2200694
State	Published - 1 Sep 2022

Keywords

Environmental surveillance
Polio type 2 (PV2)
Vaccine Derived Polio Virus (VDPV)
Whole Genome Sequencing (WGS)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.2807/1560-7917.ES.2022.27.37.2200694

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Zuckerman, N. S., Bar-Or, I., Sofer, D., Bucris, E., Morad, H., Shulman, L. M., Levi, N., Weiss, L., Aguvaev, I., Cohen, Z., Kestin, K., Vasserman, R., Elul, M., Fratty, I. S., Geva, M., Wax, M., Erster, O., Yishai, R., Hecht-Sagie, L., ... Weil, M. (2022). Emergence of genetically linked vaccine-originated poliovirus type 2 in the absence of oral polio vaccine, Jerusalem, April to July 2022. Eurosurveillance, 27(37). https://doi.org/10.2807/1560-7917.ES.2022.27.37.2200694

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title = "Emergence of genetically linked vaccine-originated poliovirus type 2 in the absence of oral polio vaccine, Jerusalem, April to July 2022",

abstract = "We report an emergence and increase in poliovirus type 2 detection via routine wastewater surveillance in three non-overlapping regions in the Jerusalem region, Israel, between April and July 2022. Sequencing showed genetic linkage among isolates and accumulation of mutations over time, with two isolates defined as vaccine-derived polioviruses (VDPV). This demonstrates the emergence and potential circulation of type 2 VDPV in a high-income country with high vaccine coverage and underscores the importance of routine wastewater surveillance during the polio eradication.",

keywords = "Environmental surveillance, Polio type 2 (PV2), Vaccine Derived Polio Virus (VDPV), Whole Genome Sequencing (WGS)",

author = "Zuckerman, {Neta S.} and Itay Bar-Or and Danit Sofer and Efrat Bucris and Hagar Morad and Shulman, {Lester M.} and Nofar Levi and Leah Weiss and Irina Aguvaev and Zvi Cohen and Klil Kestin and Rinat Vasserman and Michal Elul and Fratty, {Ilana S.} and Miranda Geva and Marina Wax and Oran Erster and Ruth Yishai and Lior Hecht-Sagie and Sharon Alroy-Preis and Ella Mendelson and Merav Weil",

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doi = "10.2807/1560-7917.ES.2022.27.37.2200694",

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Zuckerman, NS, Bar-Or, I, Sofer, D, Bucris, E, Morad, H, Shulman, LM, Levi, N, Weiss, L, Aguvaev, I, Cohen, Z, Kestin, K, Vasserman, R, Elul, M, Fratty, IS, Geva, M, Wax, M, Erster, O, Yishai, R, Hecht-Sagie, L, Alroy-Preis, S, Mendelson, E & Weil, M 2022, 'Emergence of genetically linked vaccine-originated poliovirus type 2 in the absence of oral polio vaccine, Jerusalem, April to July 2022', Eurosurveillance, vol. 27, no. 37. https://doi.org/10.2807/1560-7917.ES.2022.27.37.2200694

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T1 - Emergence of genetically linked vaccine-originated poliovirus type 2 in the absence of oral polio vaccine, Jerusalem, April to July 2022

AU - Zuckerman, Neta S.

AU - Bar-Or, Itay

AU - Sofer, Danit

AU - Bucris, Efrat

AU - Morad, Hagar

AU - Shulman, Lester M.

AU - Levi, Nofar

AU - Weiss, Leah

AU - Aguvaev, Irina

AU - Cohen, Zvi

AU - Kestin, Klil

AU - Vasserman, Rinat

AU - Elul, Michal

AU - Fratty, Ilana S.

AU - Geva, Miranda

AU - Wax, Marina

AU - Erster, Oran

AU - Yishai, Ruth

AU - Hecht-Sagie, Lior

AU - Alroy-Preis, Sharon

AU - Mendelson, Ella

AU - Weil, Merav

PY - 2022/9/1

Y1 - 2022/9/1

N2 - We report an emergence and increase in poliovirus type 2 detection via routine wastewater surveillance in three non-overlapping regions in the Jerusalem region, Israel, between April and July 2022. Sequencing showed genetic linkage among isolates and accumulation of mutations over time, with two isolates defined as vaccine-derived polioviruses (VDPV). This demonstrates the emergence and potential circulation of type 2 VDPV in a high-income country with high vaccine coverage and underscores the importance of routine wastewater surveillance during the polio eradication.

AB - We report an emergence and increase in poliovirus type 2 detection via routine wastewater surveillance in three non-overlapping regions in the Jerusalem region, Israel, between April and July 2022. Sequencing showed genetic linkage among isolates and accumulation of mutations over time, with two isolates defined as vaccine-derived polioviruses (VDPV). This demonstrates the emergence and potential circulation of type 2 VDPV in a high-income country with high vaccine coverage and underscores the importance of routine wastewater surveillance during the polio eradication.

KW - Environmental surveillance

KW - Polio type 2 (PV2)

KW - Vaccine Derived Polio Virus (VDPV)

KW - Whole Genome Sequencing (WGS)

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SN - 1560-7917

VL - 27

JO - Eurosurveillance

JF - Eurosurveillance

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ER -

Emergence of genetically linked vaccine-originated poliovirus type 2 in the absence of oral polio vaccine, Jerusalem, April to July 2022

Abstract

Keywords

UN SDGs

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