Elucidating mechanisms underlying robustness of morphogen gradients

Avigdor Eldar; Ben Zion Shilo; Naama Barkai

doi:10.1016/j.gde.2004.06.009

Elucidating mechanisms underlying robustness of morphogen gradients

Avigdor Eldar^*, Ben Zion Shilo, Naama Barkai

^*Corresponding author for this work

Weizmann Institute of Science

Research output: Contribution to journal › Review article › peer-review

84 Scopus citations

Abstract

Morphogen gradients play a pivotal role in most phases of developmental patterning. To ensure proper patterning, reproducible gradients are established under diverse environmental conditions and genetic backgrounds. We refer to the capacity to buffer fluctuations in gene dosage or environmental conditions as 'robustness'. By theoretical analysis of mechanisms that facilitate robustness, it is possible to unravel the machinery responsible for generating the spatial distribution of morphogens.

Original language	English
Pages (from-to)	435-439
Number of pages	5
Journal	Current Opinion in Genetics and Development
Volume	14
Issue number	4
DOIs	https://doi.org/10.1016/j.gde.2004.06.009
State	Published - Aug 2004
Externally published	Yes

Keywords

BMP
Decapentaplegic
Dpp
Shortened gastrulation
Sog
Tld
Tolloid
bone morphogenetic protein

Access to Document

10.1016/j.gde.2004.06.009

Cite this

@article{3d739d13132c4173b52fd84d047e2af7,

title = "Elucidating mechanisms underlying robustness of morphogen gradients",

abstract = "Morphogen gradients play a pivotal role in most phases of developmental patterning. To ensure proper patterning, reproducible gradients are established under diverse environmental conditions and genetic backgrounds. We refer to the capacity to buffer fluctuations in gene dosage or environmental conditions as 'robustness'. By theoretical analysis of mechanisms that facilitate robustness, it is possible to unravel the machinery responsible for generating the spatial distribution of morphogens.",

keywords = "BMP, Decapentaplegic, Dpp, Shortened gastrulation, Sog, Tld, Tolloid, bone morphogenetic protein",

author = "Avigdor Eldar and Shilo, {Ben Zion} and Naama Barkai",

note = "Funding Information: This work was supported by the Clore Center for Biological Physics, the Israel Science Foundation (B-Z Shilo), the Israel Science Foundation (N Barkai), and the Minerva Foundation (N Barkai). B-Z Shilo is an incumbent of the Hilda and Cecil Lewis professorial chair in Molecular Genetics. N Barkai is the incumbent of the Soretta and Henry Shapiro career development chair.",

year = "2004",

month = aug,

doi = "10.1016/j.gde.2004.06.009",

language = "אנגלית",

volume = "14",

pages = "435--439",

journal = "Current Opinion in Genetics and Development",

issn = "0959-437X",

publisher = "Elsevier Ltd.",

number = "4",

}

TY - JOUR

T1 - Elucidating mechanisms underlying robustness of morphogen gradients

AU - Eldar, Avigdor

AU - Shilo, Ben Zion

AU - Barkai, Naama

N1 - Funding Information: This work was supported by the Clore Center for Biological Physics, the Israel Science Foundation (B-Z Shilo), the Israel Science Foundation (N Barkai), and the Minerva Foundation (N Barkai). B-Z Shilo is an incumbent of the Hilda and Cecil Lewis professorial chair in Molecular Genetics. N Barkai is the incumbent of the Soretta and Henry Shapiro career development chair.

PY - 2004/8

Y1 - 2004/8

N2 - Morphogen gradients play a pivotal role in most phases of developmental patterning. To ensure proper patterning, reproducible gradients are established under diverse environmental conditions and genetic backgrounds. We refer to the capacity to buffer fluctuations in gene dosage or environmental conditions as 'robustness'. By theoretical analysis of mechanisms that facilitate robustness, it is possible to unravel the machinery responsible for generating the spatial distribution of morphogens.

AB - Morphogen gradients play a pivotal role in most phases of developmental patterning. To ensure proper patterning, reproducible gradients are established under diverse environmental conditions and genetic backgrounds. We refer to the capacity to buffer fluctuations in gene dosage or environmental conditions as 'robustness'. By theoretical analysis of mechanisms that facilitate robustness, it is possible to unravel the machinery responsible for generating the spatial distribution of morphogens.

KW - BMP

KW - Decapentaplegic

KW - Dpp

KW - Shortened gastrulation

KW - Sog

KW - Tld

KW - Tolloid

KW - bone morphogenetic protein

UR - http://www.scopus.com/inward/record.url?scp=3142583475&partnerID=8YFLogxK

U2 - 10.1016/j.gde.2004.06.009

DO - 10.1016/j.gde.2004.06.009

M3 - ???researchoutput.researchoutputtypes.contributiontojournal.systematicreview???

AN - SCOPUS:3142583475

SN - 0959-437X

VL - 14

SP - 435

EP - 439

JO - Current Opinion in Genetics and Development

JF - Current Opinion in Genetics and Development

IS - 4

ER -

Elucidating mechanisms underlying robustness of morphogen gradients

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this