Elimination characteristics of intravenously administered rIGF-I in Laron-type dwarfs

B. Klinger, M. Garty, Z. Laron

Research output: Contribution to journalArticlepeer-review

Abstract

The distribution and elimination characteristics (K(eα), K(eβ), t( 1/2 )) of an intravenous bolus of biosynthetic IGF-I administered to 10 patients with Laron-type dwarfism (LTD, 3 children and 7 adults) and 6 healthy volunteers (3 children and 3 adults) are reported. The mean (± SD) endogenous level of IGF-I in the LTD patients was 5.24 ± 2. 77 nM/l and in the controls 27.2 ± 9.4 nM/l. In the LTD patients the mean elimination constant (K(eβ)) was 0.004 ± 0.001 min-1 and t( 1/2 )= 2.6 ± 0.7 h, whereas in the controls, K(eβ) was 0.003 ± 0.009 min-1 and the t( 1/2 ) 4.4 ± 0.5 h (p < 0.05). The more rapid elimination of injected IGF-I in the LTD patients is assumed to be due to the absence of the GH-dependent 150 kDa IGF-I binding protein.

Original languageEnglish
Pages (from-to)196-199
Number of pages4
JournalDevelopmental Pharmacology and Therapeutics
Volume15
Issue number3-4
DOIs
StatePublished - 1990
Externally publishedYes

Keywords

  • IGF-I
  • IGF-I half-life
  • Laron-type dwarfism

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