Elevations of serum CA-125 predict severity of acute appendicitis in males

Yaniv Berger, Avinoam Nevler, Chaya Shwaartz, Eylon Lahat, Oded Zmora, Mordechai Gutman, Moshe Shabtai

Research output: Contribution to journalArticlepeer-review


Background: Acute appendicitis (AA) is a common indication for urgent abdominal surgery. CA-125 glycoprotein antigen is a non-specific marker for epithelial ovarian cancer; CA-125 serum levels also increased in the conditions of peritoneal inflammation. The aim of this study was to examine the correlation between serum CA-125 levels and AA. Methods: All emergency department (ED) patients with suspected AA were prospectively enrolled in the study. The serum level of CA-125 was checked in every patient on arrival to the ED in addition to the routine clinical and laboratory evaluation. Data regarding demographic, clinical, radiological, operative and pathological features were analysed. Results: One hundred consecutive patients (48 males) were enrolled in the study. We found a statistically significant correlation between CA-125 levels in males and the severity of appendicitis as described in the operative and pathology reports (P = 0.008 and P = 0.02, respectively). In addition, we observed a trend towards higher levels of CA-125 in males with AA compared with males without AA (9.9 ± 4.7 versus 7.8 ± 3.2U/mL, respectively; P = 0.09). Conclusions: CA-125 levels correlate with the severity of appendicitis in males and may serve as a surrogate marker for the severity of other intra-abdominal surgical diseases.

Original languageEnglish
Pages (from-to)260-263
Number of pages4
JournalANZ Journal of Surgery
Issue number4
StatePublished - 1 Apr 2016
Externally publishedYes


  • Acute appendicitis
  • CA-125
  • Prospective study
  • Serum biomarker


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