Elevation of serum lactic dehydrogenase levels as an early marker of occult malignant lymphoma

Z. Rotenberg, I. Weinberger, Y. Fuchs, A. Erdberg, E. Davidson, J. Agmon

Research output: Contribution to journalArticlepeer-review

Abstract

Elevated serum lactic dehydrogenase (LDH) levels, 595 to 615 μm/ml (normal < 225 μm/ml) with predominance of LDH isoenzymes 2 and 3 was the early and only sign of occult malignant lymphoma in three patients. In the first patient, overt lymphoma appeared clinically only 2 months after the finding of elevated serum LDH levels, whereas in the other two asymptomatic patients, pathologic LDH levels were the only clues to the need for further diagnostic investigation. It is concluded that LDH may have a diagnostic value in the preclinical stage of malignant lymphoma. Thus, a patient with no apparent cause for elevated serum LDH levels warrants a thorough work‐up including abdominal CT scan and even explorative laparotomy.

Original languageEnglish
Pages (from-to)1379-1381
Number of pages3
JournalCancer
Volume54
Issue number7
DOIs
StatePublished - 1 Oct 1984

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