Elevated serum alkaline phosphatase may enable early diagnosis of ovarian cancer

Alon Ben-Arie*, Zion Hagay, Herzel Ben-Hur, Magda Open, Ram Dgani

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


A case of endometrioid ovarian carcinoma associated with elevated levels of serum placental-like alkaline phosphatase (PLAP) is presented. Two and a half years before a final diagnosis was made following explorative laparotomy, an incidental blood test revealed elevated alkaline phosphatase in the patient's serum. A thorough investigation for the source of this elevation was negative. Postoperative immunohistochemical staining of the tumor, showed diffuse stain with PLAP, along with gradual decline to normal values of serum total alkaline phosphatase. It is suggested, that whenever serum alkaline phosphatase is elevated due to unknown reason, an investigation including alkaline phosphatase isoenzymes, serum Ca-125, trans-vaginal pelvic sonogram and even diagnostic laparosopy, should be considered in a search for early preclinical ovarian cancer. Copyright (C) 1999 Elsevier Science Ireland Ltd.

Original languageEnglish
Pages (from-to)69-71
Number of pages3
JournalEuropean Journal of Obstetrics, Gynecology and Reproductive Biology
Issue number1
StatePublished - Sep 1999
Externally publishedYes


  • Cancer
  • Ovary
  • Placental alkaline phosphatase


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