A case of endometrioid ovarian carcinoma associated with elevated levels of serum placental-like alkaline phosphatase (PLAP) is presented. Two and a half years before a final diagnosis was made following explorative laparotomy, an incidental blood test revealed elevated alkaline phosphatase in the patient's serum. A thorough investigation for the source of this elevation was negative. Postoperative immunohistochemical staining of the tumor, showed diffuse stain with PLAP, along with gradual decline to normal values of serum total alkaline phosphatase. It is suggested, that whenever serum alkaline phosphatase is elevated due to unknown reason, an investigation including alkaline phosphatase isoenzymes, serum Ca-125, trans-vaginal pelvic sonogram and even diagnostic laparosopy, should be considered in a search for early preclinical ovarian cancer. Copyright (C) 1999 Elsevier Science Ireland Ltd.
|Number of pages||3|
|Journal||European Journal of Obstetrics, Gynecology and Reproductive Biology|
|State||Published - Sep 1999|
- Placental alkaline phosphatase