Elevated plasma immunoreactive β-endorphin in anorexia nervosa

R. Tepper, A. Weizman*, A. Apter, S. Tyano, Y. Beyth

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Basal morning plasma levels of immunoreactive-β-endorphin (ir-β-EP), and 17-β estradiol (E2) were assessed in 25 adolescents with anorexia nervosa (AN) in comparison to 24 healthy controls. All subjects were drug free for at least 6 weeks. The mean plasma level of ir-β-EP was significantly higher (84%) in the AN patients when compared with the control subjects. The elevated plasma ir-β-EP may be relevant to the suppression of appetite, tolerance of fasting, and to the hypothalamic hypogonadism in AN.

Original languageEnglish
Pages (from-to)387-391
Number of pages5
JournalClinical Neuropharmacology
Issue number5
StatePublished - 1992
Externally publishedYes


  • Anorexia nervosa
  • Hypogonadism
  • Starvation
  • Stress
  • β-Endorphin


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