Elevated levels of serum interleukin-1 β in combat-related posttraumatic stress disorder

Baruch Spivak; Batya Shohat; Roberto Mester; Shlomit Avraham; Irit Gil-Ad; Avraham Bleich; Avi Valevski; Abraham Weizman

doi:10.1016/S0006-3223(96)00375-7

Elevated levels of serum interleukin-1 β in combat-related posttraumatic stress disorder

Baruch Spivak, Batya Shohat, Roberto Mester, Shlomit Avraham, Irit Gil-Ad, Avraham Bleich, Avi Valevski, Abraham Weizman^*

^*Corresponding author for this work

Clinical Departments

Research output: Contribution to journal › Article › peer-review

Abstract

Levels of serum interleukin-1β (IL-1β) and soluble interleukin-2 receptor (slL-2R) were assessed in 19 male patients with combat-related posttraumatic stress disorder (PTSD) in comparison to 19 age- and sex- matched healthy volunteers. Serum IL-1β levels (but not sIL-2R) were significantly higher (p < .001) in the PTSD patients than in the controls. IL-1β levels did not correlate with cortisol levels, severity of PTSD, anxiety, depressive symptoms, or alexithymia score; however, they did correlate significantly (r = .54, p < .005) with the duration of PTSD symptoms. It is possible that desensitization of the hypothalamic-pituitary- adrenal axis in chronic PTSD patients counteracts the stimulatory effect of IL-1β on cortisol secretion.

Original language	English
Pages (from-to)	345-348
Number of pages	4
Journal	Biological Psychiatry
Volume	42
Issue number	5
DOIs	https://doi.org/10.1016/S0006-3223(96)00375-7
State	Published - 1 Sep 1997

Keywords

Cortisol
Interleukin-1β
Posttraumatic stress disorder
Soluble interleukin-2 receptor

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title = "Elevated levels of serum interleukin-1 β in combat-related posttraumatic stress disorder",

abstract = "Levels of serum interleukin-1β (IL-1β) and soluble interleukin-2 receptor (slL-2R) were assessed in 19 male patients with combat-related posttraumatic stress disorder (PTSD) in comparison to 19 age- and sex- matched healthy volunteers. Serum IL-1β levels (but not sIL-2R) were significantly higher (p < .001) in the PTSD patients than in the controls. IL-1β levels did not correlate with cortisol levels, severity of PTSD, anxiety, depressive symptoms, or alexithymia score; however, they did correlate significantly (r = .54, p < .005) with the duration of PTSD symptoms. It is possible that desensitization of the hypothalamic-pituitary- adrenal axis in chronic PTSD patients counteracts the stimulatory effect of IL-1β on cortisol secretion.",

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author = "Baruch Spivak and Batya Shohat and Roberto Mester and Shlomit Avraham and Irit Gil-Ad and Avraham Bleich and Avi Valevski and Abraham Weizman",

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T1 - Elevated levels of serum interleukin-1 β in combat-related posttraumatic stress disorder

AU - Spivak, Baruch

AU - Shohat, Batya

AU - Mester, Roberto

AU - Avraham, Shlomit

AU - Gil-Ad, Irit

AU - Bleich, Avraham

AU - Valevski, Avi

AU - Weizman, Abraham

PY - 1997/9/1

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N2 - Levels of serum interleukin-1β (IL-1β) and soluble interleukin-2 receptor (slL-2R) were assessed in 19 male patients with combat-related posttraumatic stress disorder (PTSD) in comparison to 19 age- and sex- matched healthy volunteers. Serum IL-1β levels (but not sIL-2R) were significantly higher (p < .001) in the PTSD patients than in the controls. IL-1β levels did not correlate with cortisol levels, severity of PTSD, anxiety, depressive symptoms, or alexithymia score; however, they did correlate significantly (r = .54, p < .005) with the duration of PTSD symptoms. It is possible that desensitization of the hypothalamic-pituitary- adrenal axis in chronic PTSD patients counteracts the stimulatory effect of IL-1β on cortisol secretion.

AB - Levels of serum interleukin-1β (IL-1β) and soluble interleukin-2 receptor (slL-2R) were assessed in 19 male patients with combat-related posttraumatic stress disorder (PTSD) in comparison to 19 age- and sex- matched healthy volunteers. Serum IL-1β levels (but not sIL-2R) were significantly higher (p < .001) in the PTSD patients than in the controls. IL-1β levels did not correlate with cortisol levels, severity of PTSD, anxiety, depressive symptoms, or alexithymia score; however, they did correlate significantly (r = .54, p < .005) with the duration of PTSD symptoms. It is possible that desensitization of the hypothalamic-pituitary- adrenal axis in chronic PTSD patients counteracts the stimulatory effect of IL-1β on cortisol secretion.

KW - Cortisol

KW - Interleukin-1β

KW - Posttraumatic stress disorder

KW - Soluble interleukin-2 receptor

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DO - 10.1016/S0006-3223(96)00375-7

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JO - Biological Psychiatry

JF - Biological Psychiatry

SN - 0006-3223

IS - 5

ER -

Elevated levels of serum interleukin-1 β in combat-related posttraumatic stress disorder

Abstract

Keywords

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