Elevated levels of serum interleukin-1 β in combat-related posttraumatic stress disorder

Baruch Spivak, Batya Shohat, Roberto Mester, Shlomit Avraham, Irit Gil-Ad, Avraham Bleich, Avi Valevski, Abraham Weizman*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Levels of serum interleukin-1β (IL-1β) and soluble interleukin-2 receptor (slL-2R) were assessed in 19 male patients with combat-related posttraumatic stress disorder (PTSD) in comparison to 19 age- and sex- matched healthy volunteers. Serum IL-1β levels (but not sIL-2R) were significantly higher (p < .001) in the PTSD patients than in the controls. IL-1β levels did not correlate with cortisol levels, severity of PTSD, anxiety, depressive symptoms, or alexithymia score; however, they did correlate significantly (r = .54, p < .005) with the duration of PTSD symptoms. It is possible that desensitization of the hypothalamic-pituitary- adrenal axis in chronic PTSD patients counteracts the stimulatory effect of IL-1β on cortisol secretion.

Original languageEnglish
Pages (from-to)345-348
Number of pages4
JournalBiological Psychiatry
Issue number5
StatePublished - 1 Sep 1997


  • Cortisol
  • Interleukin-1β
  • Posttraumatic stress disorder
  • Soluble interleukin-2 receptor


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