Elevated levels of interleukin-6 in the follicular fluid at the time of oocyte retrieval for in vitro fertilization may predict the development of early-form ovarian hyperstimulation syndrome

Eli Geva, Foad Azem, Joseph B. Lessing, Israel Yovel, Liat Lerner-Geva, Ami Amit

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: To determine the possible predictive role of interleukin-2 (IL-2), IL-6, and tumor necrosis factor (TNF-α) in the development of early- form ovarian hyperstimulation syndrome (OHSS). Design: Nested, case-control study. Setting: An IVF unit, university-based program. Patient(s): Follicular fluid (FF) was obtained from 322 high responders. The study group and control group comprised 10 patients who developed early, severe OHSS and 10 who did not develop OHSS, respectively. An additional control group included 10 low- responder patients who did not develop OHSS. Intervention(s): Ovulation induction with hMG combined with GnRH analogue. Main Outcome Measure(s): All FF samples were tested in IL-2, IL-6, and TNF-α. The patient's serum was tested for mean E2 and P concentrations. Result(s): Interleukin-6 levels in the FF were significantly higher in the OHSS group than in the two control groups, whereas no differences were found in IL-2 and TNF-α. No correlation was found between the FF concentrations of IL-2, IL-6, and TNF-α and the mean serum E2 levels or the number of oocytes retrieved. Conclusion(s): Elevated levels of IL-6 in the preovulatory FF at the time of oocyte retrieval for IVF may predict the development of early-form OHSS in high responders.

Original languageEnglish
Pages (from-to)133-137
Number of pages5
JournalFertility and Sterility
Volume68
Issue number1
DOIs
StatePublished - Jul 1997

Keywords

  • IL-2
  • IL-6
  • IVF
  • OHSS
  • TNF-α

Fingerprint

Dive into the research topics of 'Elevated levels of interleukin-6 in the follicular fluid at the time of oocyte retrieval for in vitro fertilization may predict the development of early-form ovarian hyperstimulation syndrome'. Together they form a unique fingerprint.

Cite this