TY - JOUR
T1 - Elevated expression of galectin-3, thioredoxin and thioredoxin interacting protein in preeclampsia
AU - Farladansky-Gershnabel, Sivan
AU - Heusler, Ishai
AU - Biron-Shental, Tal
AU - Shechter-Maor, Gil
AU - Amiel, Aliza
AU - Kidron, Debora
AU - Weisz, Avivit
AU - Einbinder, Yael
AU - Cohen-Hagai, Keren
AU - Benchetrit, Sydney
AU - Zitman-Gal, Tali
N1 - Publisher Copyright:
© 2021 International Society for the Study of Hypertension in Pregnancy
PY - 2021/12
Y1 - 2021/12
N2 - Objectives: Preeclampsia (PE) is a pregnancy-related syndrome characterized by the onset of hypertension and proteinuria that can lead to end-organ dysfunction. Galectin-3 (Gal-3) is involved in cell growth, differentiation, inflammation and fibrosis. Thioredoxin (TXN) acts as antioxidant enzyme in several cellular processes, regulating inflammation and inhibiting apoptosis. TXNIP is an endogenous inhibitor of TXN. We evaluated changes in the inflammatory response of Gal-3, TXN, and TXNIP at the level of maternal blood, placenta, and umbilical cord blood of women with PE. Study design: Ten women with PE and 20 with normal pregnancy (NP) were recruited during admission for delivery. Blood samples were obtained from parturients and umbilical cords, and placental tissue for analysis. Results: Gal-3 and TXNIP mRNA expression were higher in maternal plasma in PE group compared to NP and were lower in cord blood plasma and placentas in the PE group. In the PE group, TXN/TXNIP mRNA ratio was higher in cord blood plasma (2.07) compared to maternal plasma (1.09). TXN/TXNIP placental protein ratio was similar between PE (0.89) and NP (0.79). ELISA demonstrated that Gal-3 levels in maternal serum were significantly higher in the PE vs. the NP group. Conclusions: Pro-inflammatory changes were expressed by high Gal-3 and TXNIP mRNA in maternal blood of PE women, but not in their placental and cord blood samples. These findings may imply that the placenta has a role in protecting the fetus from the damages of inflammatory response, which is more common in PE than in NP.
AB - Objectives: Preeclampsia (PE) is a pregnancy-related syndrome characterized by the onset of hypertension and proteinuria that can lead to end-organ dysfunction. Galectin-3 (Gal-3) is involved in cell growth, differentiation, inflammation and fibrosis. Thioredoxin (TXN) acts as antioxidant enzyme in several cellular processes, regulating inflammation and inhibiting apoptosis. TXNIP is an endogenous inhibitor of TXN. We evaluated changes in the inflammatory response of Gal-3, TXN, and TXNIP at the level of maternal blood, placenta, and umbilical cord blood of women with PE. Study design: Ten women with PE and 20 with normal pregnancy (NP) were recruited during admission for delivery. Blood samples were obtained from parturients and umbilical cords, and placental tissue for analysis. Results: Gal-3 and TXNIP mRNA expression were higher in maternal plasma in PE group compared to NP and were lower in cord blood plasma and placentas in the PE group. In the PE group, TXN/TXNIP mRNA ratio was higher in cord blood plasma (2.07) compared to maternal plasma (1.09). TXN/TXNIP placental protein ratio was similar between PE (0.89) and NP (0.79). ELISA demonstrated that Gal-3 levels in maternal serum were significantly higher in the PE vs. the NP group. Conclusions: Pro-inflammatory changes were expressed by high Gal-3 and TXNIP mRNA in maternal blood of PE women, but not in their placental and cord blood samples. These findings may imply that the placenta has a role in protecting the fetus from the damages of inflammatory response, which is more common in PE than in NP.
KW - Galectin-3
KW - Hypertension
KW - Preeclampsia
KW - Thioredoxin
KW - Thioredoxin-interacting protein
UR - http://www.scopus.com/inward/record.url?scp=85117699378&partnerID=8YFLogxK
U2 - 10.1016/j.preghy.2021.10.003
DO - 10.1016/j.preghy.2021.10.003
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C2 - 34700108
AN - SCOPUS:85117699378
SN - 2210-7789
VL - 26
SP - 95
EP - 101
JO - Pregnancy Hypertension
JF - Pregnancy Hypertension
ER -