Electrostatic interaction of myristoylated proteins with membranes: Simple physics, complicated biology

Diana Murray, Nir Ben-Tal, Barry Honig, Stuart McLaughlin*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

Cell membrane association by several important peripheral proteins, such as Src, MARCKS, HIV-1 Gag, and K-Ras, requires nonspecific electrostatic interactions between a cluster of basic residues on the protein and acidic phospholipids in the plasma membrane. A simple theoretical model based on the nonlinear Poisson-Boltzmann equation describes well the experimentally measured electrostatic association between such proteins and the cell membrane.

Original languageEnglish
Pages (from-to)985-989
Number of pages5
JournalStructure
Volume5
Issue number8
DOIs
StatePublished - 1997

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