TY - JOUR
T1 - Electromagnetic field at 15.95-16 Hz is cardio protective following acute myocardial infarction
AU - Barzelai, Sharon
AU - Dayan, Anat
AU - Feinberg, Micha S.
AU - Holbova, Radka
AU - Laniado, Shlomo
AU - Scheinowitz, Mickey
PY - 2009/10
Y1 - 2009/10
N2 - Previous studies have shown that pre-exposure of the heart to weak magnetic field reduces infarct size shortly after induction of myocardial ischemia. To investigate the role of AC magnetic field with a frequency of 15.95-16 Hz and 80 mT on left ventricular (LV) remodeling following chronic coronary occlusion and a short episode of ischemia followed by reperfusion (I/R). LV dimension and function were measured using echocardiography. Femur bone marrow was isolated and cells were phenotyped for endothelial linage and immuno stained for endothelial cells. The area at risk was measured using triphenyltetrazolium chloride staining. A significant reduction of 27% in shortening fraction (SF) was measured following acute myocardial infarction (AMI) compared with a 7% decrease in animals exposed to magnetic field (p < 0.04). A significantly higher number of colony forming units and endothelial progenitor cells were counted within the treated groups subjected to magnetic field (p < 0.02). Exposing the heart to magnetic field prior to reperfusion did not show any preservation either on SF or on infarct size. Magnetic field was protective in the AMI but not in the I/R model. The mechanisms underlying cardiac protection induced by AC magnetic field following chronic injury deserves further investigation.
AB - Previous studies have shown that pre-exposure of the heart to weak magnetic field reduces infarct size shortly after induction of myocardial ischemia. To investigate the role of AC magnetic field with a frequency of 15.95-16 Hz and 80 mT on left ventricular (LV) remodeling following chronic coronary occlusion and a short episode of ischemia followed by reperfusion (I/R). LV dimension and function were measured using echocardiography. Femur bone marrow was isolated and cells were phenotyped for endothelial linage and immuno stained for endothelial cells. The area at risk was measured using triphenyltetrazolium chloride staining. A significant reduction of 27% in shortening fraction (SF) was measured following acute myocardial infarction (AMI) compared with a 7% decrease in animals exposed to magnetic field (p < 0.04). A significantly higher number of colony forming units and endothelial progenitor cells were counted within the treated groups subjected to magnetic field (p < 0.02). Exposing the heart to magnetic field prior to reperfusion did not show any preservation either on SF or on infarct size. Magnetic field was protective in the AMI but not in the I/R model. The mechanisms underlying cardiac protection induced by AC magnetic field following chronic injury deserves further investigation.
KW - Colony forming units
KW - Echocardiography
KW - Endothelial progenitor cells
KW - Ischemia/reperfusion
KW - Rats
UR - http://www.scopus.com/inward/record.url?scp=70349194520&partnerID=8YFLogxK
U2 - 10.1007/s10439-009-9758-2
DO - 10.1007/s10439-009-9758-2
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C2 - 19588249
AN - SCOPUS:70349194520
SN - 0090-6964
VL - 37
SP - 2093
EP - 2104
JO - Annals of Biomedical Engineering
JF - Annals of Biomedical Engineering
IS - 10
ER -
