Electrolytic lesion of globus pallidus ameliorates the behavioral and neurodegenerative effects of quinolinic acid lesion of the striatum: A potential novel treatment in a rat model of Huntington's disease

D. Joel; L. Ayalon; R. Tarrasch; L. Veenman; J. Feldon; I. Weiner

doi:10.1016/S0006-8993(97)01428-5

Electrolytic lesion of globus pallidus ameliorates the behavioral and neurodegenerative effects of quinolinic acid lesion of the striatum: A potential novel treatment in a rat model of Huntington's disease

D. Joel, L. Ayalon, R. Tarrasch, L. Veenman, J. Feldon, I. Weiner^*

^*Corresponding author for this work

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27 Scopus citations

Abstract

Bilateral electrolytic pallidal lesion ameliorated the deleterious effects of bilateral quinolinic acid (QA) lesion to the striatum on post- surgery weight, activity level, and performance in a water maze task, and reduced the extent of striatal damage. Given that the neurodegenerative and behavioral effects of QA striatal lesion are thought to mimic those seen in Huntington's disease, these results may point to a potential novel treatment for this disease.

Original language	English
Pages (from-to)	143-148
Number of pages	6
Journal	Brain Research
Volume	787
Issue number	1
DOIs	https://doi.org/10.1016/S0006-8993(97)01428-5
State	Published - 16 Mar 1998

Keywords

Basal ganglia
Globus Pallidus
Huntington's disease
Lesion
Quinolinic acid
Rat
Striatum
Water maze

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title = "Electrolytic lesion of globus pallidus ameliorates the behavioral and neurodegenerative effects of quinolinic acid lesion of the striatum: A potential novel treatment in a rat model of Huntington's disease",

abstract = "Bilateral electrolytic pallidal lesion ameliorated the deleterious effects of bilateral quinolinic acid (QA) lesion to the striatum on post- surgery weight, activity level, and performance in a water maze task, and reduced the extent of striatal damage. Given that the neurodegenerative and behavioral effects of QA striatal lesion are thought to mimic those seen in Huntington's disease, these results may point to a potential novel treatment for this disease.",

keywords = "Basal ganglia, Globus Pallidus, Huntington's disease, Lesion, Quinolinic acid, Rat, Striatum, Water maze",

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Joel, D, Ayalon, L, Tarrasch, R, Veenman, L, Feldon, J & Weiner, I 1998, 'Electrolytic lesion of globus pallidus ameliorates the behavioral and neurodegenerative effects of quinolinic acid lesion of the striatum: A potential novel treatment in a rat model of Huntington's disease', Brain Research, vol. 787, no. 1, pp. 143-148. https://doi.org/10.1016/S0006-8993(97)01428-5

Electrolytic lesion of globus pallidus ameliorates the behavioral and neurodegenerative effects of quinolinic acid lesion of the striatum: A potential novel treatment in a rat model of Huntington's disease. / Joel, D.; Ayalon, L.; Tarrasch, R. et al.
In: Brain Research, Vol. 787, No. 1, 16.03.1998, p. 143-148.

Research output: Contribution to journal › Article › peer-review

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AU - Feldon, J.

AU - Weiner, I.

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Electrolytic lesion of globus pallidus ameliorates the behavioral and neurodegenerative effects of quinolinic acid lesion of the striatum: A potential novel treatment in a rat model of Huntington's disease

Abstract

Keywords

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