Electrochemical transduction of liposome-amplified DNA sensing

Fernando Patolsky, Amir Lichtenstein, Itamar Willner*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


The formation of double-stranded DNA on electrodes can be probed and amplified with functionalized liposomes (shown schematically). The resulting charged interface strongly repels the redox label, [Fe(CN)6]3- /[Fe(CN)6]4-, from the electrode interface, resulting in a high electron transfer resistance. Faradaic impedance spectroscopy is used to transduce the biosensing events.

Original languageEnglish
Pages (from-to)940-943
Number of pages4
JournalAngewandte Chemie - International Edition
Issue number5
StatePublished - 3 Mar 2000
Externally publishedYes


  • Biosensors
  • DNA recognition
  • Impedance spectroscopy
  • Liposomes
  • Monolayers


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