Electrochemical transduction of liposome-amplified DNA sensing

Fernando Patolsky; Amir Lichtenstein; Itamar Willner

doi:10.1002/(SICI)1521-3773(20000303)39:5<940::AID-ANIE940>3.0.CO;2-Y

Electrochemical transduction of liposome-amplified DNA sensing

Fernando Patolsky, Amir Lichtenstein, Itamar Willner^*

^*Corresponding author for this work

Hebrew University of Jerusalem

Research output: Contribution to journal › Article › peer-review

137 Scopus citations

Abstract

The formation of double-stranded DNA on electrodes can be probed and amplified with functionalized liposomes (shown schematically). The resulting charged interface strongly repels the redox label, [Fe(CN)₆]^3- /[Fe(CN)₆]^4-, from the electrode interface, resulting in a high electron transfer resistance. Faradaic impedance spectroscopy is used to transduce the biosensing events.

Original language	English
Pages (from-to)	940-943
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	39
Issue number	5
DOIs	https://doi.org/10.1002/(SICI)1521-3773(20000303)39:5<940::AID-ANIE940>3.0.CO;2-Y
State	Published - 3 Mar 2000
Externally published	Yes

Keywords

Biosensors
DNA recognition
Impedance spectroscopy
Liposomes
Monolayers

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10.1002/(SICI)1521-3773(20000303)39:5<940::AID-ANIE940>3.0.CO;2-Y

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AU - Lichtenstein, Amir

AU - Willner, Itamar

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N2 - The formation of double-stranded DNA on electrodes can be probed and amplified with functionalized liposomes (shown schematically). The resulting charged interface strongly repels the redox label, [Fe(CN)6]3- /[Fe(CN)6]4-, from the electrode interface, resulting in a high electron transfer resistance. Faradaic impedance spectroscopy is used to transduce the biosensing events.

AB - The formation of double-stranded DNA on electrodes can be probed and amplified with functionalized liposomes (shown schematically). The resulting charged interface strongly repels the redox label, [Fe(CN)6]3- /[Fe(CN)6]4-, from the electrode interface, resulting in a high electron transfer resistance. Faradaic impedance spectroscopy is used to transduce the biosensing events.

KW - Biosensors

KW - DNA recognition

KW - Impedance spectroscopy

KW - Liposomes

KW - Monolayers

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Electrochemical transduction of liposome-amplified DNA sensing

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Keywords

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