Electrochemical DNAzyme-based biosensors for disease diagnosis

Richa Pandey; Yang Lu; Erin M. McConnell; Enas Osman; Alexander Scott; Jimmy Gu; Todd Hoare; Leyla Soleymani; Yingfu Li

doi:10.1016/j.bios.2022.114983

Electrochemical DNAzyme-based biosensors for disease diagnosis

Richa Pandey^*, Yang Lu, Erin M. McConnell, Enas Osman, Alexander Scott, Jimmy Gu, Todd Hoare, Leyla Soleymani^*, Yingfu Li^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

DNAzyme-based electrochemical biosensors provide exceptional analytical sensitivity and high target recognition specificity for disease diagnosis. This review provides a critical perspective on the fundamental and applied impact of incorporating DNAzymes in the field of electrochemical biosensing. Specifically, we highlight recent advances in creating DNAzyme-based electrochemical biosensors for diagnosing infectious diseases, cancer and regulatory diseases. We also develop an understanding of challenges around translating the research in the field of DNAzyme-based electrochemical biosensors from labs to clinics, followed by a discussion on different strategies that can be applied to enhance the performance of the currently existing technologies to create truly point-of-care electrochemical DNAzyme biosensors.

Original language	English
Article number	114983
Journal	Biosensors and Bioelectronics
Volume	224
DOIs	https://doi.org/10.1016/j.bios.2022.114983
State	Published - 15 Mar 2023
Externally published	Yes

Keywords

DNAzyme
Electrochemical biosensor
Functional nucleic acid
Point of care diagnostics

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.bios.2022.114983

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title = "Electrochemical DNAzyme-based biosensors for disease diagnosis",

abstract = "DNAzyme-based electrochemical biosensors provide exceptional analytical sensitivity and high target recognition specificity for disease diagnosis. This review provides a critical perspective on the fundamental and applied impact of incorporating DNAzymes in the field of electrochemical biosensing. Specifically, we highlight recent advances in creating DNAzyme-based electrochemical biosensors for diagnosing infectious diseases, cancer and regulatory diseases. We also develop an understanding of challenges around translating the research in the field of DNAzyme-based electrochemical biosensors from labs to clinics, followed by a discussion on different strategies that can be applied to enhance the performance of the currently existing technologies to create truly point-of-care electrochemical DNAzyme biosensors.",

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AU - Pandey, Richa

AU - Lu, Yang

AU - McConnell, Erin M.

AU - Osman, Enas

AU - Scott, Alexander

AU - Gu, Jimmy

AU - Hoare, Todd

AU - Soleymani, Leyla

AU - Li, Yingfu

PY - 2023/3/15

Y1 - 2023/3/15

N2 - DNAzyme-based electrochemical biosensors provide exceptional analytical sensitivity and high target recognition specificity for disease diagnosis. This review provides a critical perspective on the fundamental and applied impact of incorporating DNAzymes in the field of electrochemical biosensing. Specifically, we highlight recent advances in creating DNAzyme-based electrochemical biosensors for diagnosing infectious diseases, cancer and regulatory diseases. We also develop an understanding of challenges around translating the research in the field of DNAzyme-based electrochemical biosensors from labs to clinics, followed by a discussion on different strategies that can be applied to enhance the performance of the currently existing technologies to create truly point-of-care electrochemical DNAzyme biosensors.

AB - DNAzyme-based electrochemical biosensors provide exceptional analytical sensitivity and high target recognition specificity for disease diagnosis. This review provides a critical perspective on the fundamental and applied impact of incorporating DNAzymes in the field of electrochemical biosensing. Specifically, we highlight recent advances in creating DNAzyme-based electrochemical biosensors for diagnosing infectious diseases, cancer and regulatory diseases. We also develop an understanding of challenges around translating the research in the field of DNAzyme-based electrochemical biosensors from labs to clinics, followed by a discussion on different strategies that can be applied to enhance the performance of the currently existing technologies to create truly point-of-care electrochemical DNAzyme biosensors.

KW - DNAzyme

KW - Electrochemical biosensor

KW - Functional nucleic acid

KW - Point of care diagnostics

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Electrochemical DNAzyme-based biosensors for disease diagnosis

Abstract

Keywords

UN SDGs

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