Electrochemical DNAzyme-based biosensors for disease diagnosis

Richa Pandey*, Yang Lu, Erin M. McConnell, Enas Osman, Alexander Scott, Jimmy Gu, Todd Hoare, Leyla Soleymani*, Yingfu Li*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


DNAzyme-based electrochemical biosensors provide exceptional analytical sensitivity and high target recognition specificity for disease diagnosis. This review provides a critical perspective on the fundamental and applied impact of incorporating DNAzymes in the field of electrochemical biosensing. Specifically, we highlight recent advances in creating DNAzyme-based electrochemical biosensors for diagnosing infectious diseases, cancer and regulatory diseases. We also develop an understanding of challenges around translating the research in the field of DNAzyme-based electrochemical biosensors from labs to clinics, followed by a discussion on different strategies that can be applied to enhance the performance of the currently existing technologies to create truly point-of-care electrochemical DNAzyme biosensors.

Original languageEnglish
Article number114983
JournalBiosensors and Bioelectronics
StatePublished - 15 Mar 2023
Externally publishedYes


  • DNAzyme
  • Electrochemical biosensor
  • Functional nucleic acid
  • Point of care diagnostics


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