Electrical impedance scanning for breast cancer risk stratification in young women

Alexander Stojadinovic, Aviram Nissan, Craig D. Shriver, Sarah Lenington, David Gur

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Background: Electrical Impedance Scanning (EIS) measures changes in breast tissue associated with breast cancer development. The T-Scan™ 2000ED is designed to use EIS to identify women ages 30-39 with elevated risk of breast cancer (i.e. T-Scan+ women). Aim: To estimate the relative risk of breast cancer in a T-Scan+ woman compared to a randomly-selected young woman. Methods: A prospective, cohort arm trial was conducted in pre-menopausal women. T-Scan specificity was evaluated in a cohort of 1,751 healthy women ages 30-39. T-Scan sensitivity was tested in a cohort of 390 women ages 30-45 scheduled for biopsy. Relative risk of breast cancer at time of exam was calculated for T-Scan+ women. Results: T-Scan specificity was 94.7% (95%CI: 93.7%-95.7%). T-Scan sensitivity was 26.4% (95%CI: 17.4%-35.4%). There were 23 of 87 biopsy-proven T-Scan+ cancers. The relative risk of a T-Scan+ woman having breast cancer is 4.95 (95%CI: 3.16-7.14). Conclusion: EIS can identify a subset of young women with a relative risk of breast cancer almost 5 times greater than in the population of young women at-large. T-Scan+ women have a sufficiently high risk of breast cancer to warrant further surveillance or imaging.

Original languageEnglish
Title of host publication13th International Conference on Electrical Bioimpedance and the 8th Conference on Electrical Impedance Tomography 2007, ICEBI 2007
PublisherSpringer Verlag
Pages675-678
Number of pages4
ISBN (Print)9783540738404
DOIs
StatePublished - 2007
Externally publishedYes

Publication series

NameIFMBE Proceedings
Volume17 IFMBE
ISSN (Print)1680-0737

Keywords

  • Breast cancer
  • Electrical impedance
  • Screening

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