Elastic properties of the excised lungs of NZB/W mice and their correlation with histopathologic changes

David Struhar, Ronald Harbeck, Reuben Cherniack

Research output: Contribution to journalArticlepeer-review

Abstract

Lung volume and the pressure-volume (PV) relationships of the lung were determined in excised lungs of an animal model of human systemic lupus erythematosus, which develops in NZB/W mice, and correlated with histopathologic changes. In young, 4-month-old NZB/W mice, and in nonautoimmune BALB/c mice at any age, there were minimal histologic changes or alterations in lung function. The NZB/W mice developed histologic changes with aging. Perivascular, peribronchial, and interstitial changes developed and were associated with a significant reduction in total lung capacity as well as changes in the pressure-volume characteristics of the lung, which are compatible with a restrictive process.

Original languageEnglish
Pages (from-to)107-112
Number of pages6
JournalLung
Volume166
Issue number1
DOIs
StatePublished - Dec 1988
Externally publishedYes

Keywords

  • Lung elasticity
  • NZB/W
  • Pressure-volume relationship
  • Total lung capacity
  • mice

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