TY - JOUR
T1 - Eight novel serine proteases inhibitors from a water bloom of the cyanobacterium Microcystis sp.
AU - Zafrir-Ilan, Ella
AU - Carmeli, Shmuel
N1 - Funding Information:
We thank Noam Tal, The Mass Spectrometry Laboratory of The School of Chemistry, Tel Aviv University, for the ESI mass spectra measurements, and Karin Shereshevsky, The Mass Spectrometry Laboratory of The Maiman Institute for Proteome Research of Tel Aviv University, for the MALDI mass spectra measurements. This research was supported by the Israel Science Foundation grant 776/06 .
PY - 2010/11/20
Y1 - 2010/11/20
N2 - Eight new secondary metabolites, micropeptin MM836 (1), micropeptin MM850 (2), micropeptin MM916 (3), micropeptin MM932 (4), micropeptin MM978 (5), anabaenopeptin MM823 (6), anabaenopeptin MM850 (7), and anabaenopeptin MM913 (8), as well as the known anabaenopeptin B (9) were isolated from the hydrophilic extract of the cyanobacterium Microcystis sp. that was collected from a fishpond in Kibbutz Ma'agan Michael, Israel, in September 2006. The structure of the pure natural products was established by spectroscopic methods including 1D and 2D NMR, UV, and MS techniques. The absolute configuration of the chiral centers of the compounds was determined using Marfey's method. The inhibitory activity of the compounds was determined against the serine proteases, trypsin, chymotrypsin, thrombin and elastase.
AB - Eight new secondary metabolites, micropeptin MM836 (1), micropeptin MM850 (2), micropeptin MM916 (3), micropeptin MM932 (4), micropeptin MM978 (5), anabaenopeptin MM823 (6), anabaenopeptin MM850 (7), and anabaenopeptin MM913 (8), as well as the known anabaenopeptin B (9) were isolated from the hydrophilic extract of the cyanobacterium Microcystis sp. that was collected from a fishpond in Kibbutz Ma'agan Michael, Israel, in September 2006. The structure of the pure natural products was established by spectroscopic methods including 1D and 2D NMR, UV, and MS techniques. The absolute configuration of the chiral centers of the compounds was determined using Marfey's method. The inhibitory activity of the compounds was determined against the serine proteases, trypsin, chymotrypsin, thrombin and elastase.
KW - Anabaenopeptins
KW - Cyanobacteria
KW - Microcystis
KW - Micropeptins
KW - Natural products
UR - http://www.scopus.com/inward/record.url?scp=78049261844&partnerID=8YFLogxK
U2 - 10.1016/j.tet.2010.09.067
DO - 10.1016/j.tet.2010.09.067
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AN - SCOPUS:78049261844
SN - 0040-4020
VL - 66
SP - 9194
EP - 9202
JO - Tetrahedron
JF - Tetrahedron
IS - 47
ER -