Eight new peptaibols from sponge-associated Trichoderma atroviride

Irina Panizel, Oded Yarden, Micha Ilan, Shmuel Carmeli*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

33 Scopus citations


Eight new and four known peptaibols were isolated from a strain of the fungus, Trichoderma atroviride (NF16), which was cultured from an Axinellid sponge collected from the East Mediterranean coast of Israel. The structures of the pure compounds were determined using HRMS, MS/MS and one- and two-dimensional NMR measurements. The isolated compounds belong to the trichorzianines, a family of 19-residue linear hydrophobic peptides containing a high proportion of α-aminoisobutyric acid (Aib), an acetylated N-terminus and a C-terminal amino alcohol. These new peptaibols exhibited antimicrobial activity against environmental bacteria isolated from the Mediterranean coast of Israel.

Original languageEnglish
Pages (from-to)4937-4960
Number of pages24
JournalMarine Drugs
Issue number12
StatePublished - Dec 2013


  • Axinella polypoides
  • Axinella verrucosa
  • Peptaibols
  • Trichoderma atroviride
  • Trichorzianines


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